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000269033 1001_ $$0P:(DE-2719)2812474$$aBarnstedt, Oliver$$b0$$eFirst author$$udzne
000269033 245__ $$aA hippocampus-accumbens code guides goal-directed appetitive behavior.
000269033 260__ $$a[London]$$bNature Publishing Group UK$$c2024
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000269033 520__ $$aThe dorsal hippocampus (dHPC) is a key brain region for the expression of spatial memories, such as navigating towards a learned reward location. The nucleus accumbens (NAc) is a prominent projection target of dHPC and implicated in value-based action selection. Yet, the contents of the dHPC→NAc information stream and their acute role in behavior remain largely unknown. Here, we found that optogenetic stimulation of the dHPC→NAc pathway while mice navigated towards a learned reward location was both necessary and sufficient for spatial memory-related appetitive behaviors. To understand the task-relevant coding properties of individual NAc-projecting hippocampal neurons (dHPC→NAc), we used in vivo dual-color two-photon imaging. In contrast to other dHPC neurons, the dHPC→NAc subpopulation contained more place cells, with enriched spatial tuning properties. This subpopulation also showed enhanced coding of non-spatial task-relevant behaviors such as deceleration and appetitive licking. A generalized linear model revealed enhanced conjunctive coding in dHPC→NAc neurons which improved the identification of the reward zone. We propose that dHPC routes specific reward-related spatial and behavioral state information to guide NAc action selection.
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000269033 650_2 $$2MeSH$$aAnimals
000269033 650_2 $$2MeSH$$aMice
000269033 650_2 $$2MeSH$$aGoals
000269033 650_2 $$2MeSH$$aHippocampus
000269033 650_2 $$2MeSH$$aAppetitive Behavior
000269033 650_2 $$2MeSH$$aSpatial Memory
000269033 650_2 $$2MeSH$$aPhospholipid Ethers
000269033 650_7 $$2NLM Chemicals$$a1,2-dihexadecyl-sn-glycero-3-phosphocholine
000269033 650_7 $$2NLM Chemicals$$aPhospholipid Ethers
000269033 7001_ $$0P:(DE-2719)2812099$$aMocellin, Petra$$b1$$udzne
000269033 7001_ $$0P:(DE-2719)2810375$$aRemy, Stefan$$b2$$eLast author$$udzne
000269033 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-024-47361-x$$gVol. 15, no. 1, p. 3196$$n1$$p3196$$tNature Communications$$v15$$x2041-1723$$y2024
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