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@ARTICLE{Barnstedt:269033,
      author       = {Barnstedt, Oliver and Mocellin, Petra and Remy, Stefan},
      title        = {{A} hippocampus-accumbens code guides goal-directed
                      appetitive behavior.},
      journal      = {Nature Communications},
      volume       = {15},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DZNE-2024-00464},
      pages        = {3196},
      year         = {2024},
      abstract     = {The dorsal hippocampus (dHPC) is a key brain region for the
                      expression of spatial memories, such as navigating towards a
                      learned reward location. The nucleus accumbens (NAc) is a
                      prominent projection target of dHPC and implicated in
                      value-based action selection. Yet, the contents of the
                      dHPC→NAc information stream and their acute role in
                      behavior remain largely unknown. Here, we found that
                      optogenetic stimulation of the dHPC→NAc pathway while mice
                      navigated towards a learned reward location was both
                      necessary and sufficient for spatial memory-related
                      appetitive behaviors. To understand the task-relevant coding
                      properties of individual NAc-projecting hippocampal neurons
                      (dHPC→NAc), we used in vivo dual-color two-photon imaging.
                      In contrast to other dHPC neurons, the dHPC→NAc
                      subpopulation contained more place cells, with enriched
                      spatial tuning properties. This subpopulation also showed
                      enhanced coding of non-spatial task-relevant behaviors such
                      as deceleration and appetitive licking. A generalized linear
                      model revealed enhanced conjunctive coding in dHPC→NAc
                      neurons which improved the identification of the reward
                      zone. We propose that dHPC routes specific reward-related
                      spatial and behavioral state information to guide NAc action
                      selection.},
      keywords     = {Animals / Mice / Goals / Hippocampus / Appetitive Behavior
                      / Spatial Memory / Phospholipid Ethers /
                      1,2-dihexadecyl-sn-glycero-3-phosphocholine (NLM Chemicals)
                      / Phospholipid Ethers (NLM Chemicals)},
      cin          = {AG Remy},
      ddc          = {500},
      cid          = {I:(DE-2719)1013006},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38609363},
      pmc          = {pmc:PMC11015045},
      doi          = {10.1038/s41467-024-47361-x},
      url          = {https://pub.dzne.de/record/269033},
}