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024 7 _ |a 10.1038/s41467-024-47361-x
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100 1 _ |a Barnstedt, Oliver
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245 _ _ |a A hippocampus-accumbens code guides goal-directed appetitive behavior.
260 _ _ |a [London]
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520 _ _ |a The dorsal hippocampus (dHPC) is a key brain region for the expression of spatial memories, such as navigating towards a learned reward location. The nucleus accumbens (NAc) is a prominent projection target of dHPC and implicated in value-based action selection. Yet, the contents of the dHPC→NAc information stream and their acute role in behavior remain largely unknown. Here, we found that optogenetic stimulation of the dHPC→NAc pathway while mice navigated towards a learned reward location was both necessary and sufficient for spatial memory-related appetitive behaviors. To understand the task-relevant coding properties of individual NAc-projecting hippocampal neurons (dHPC→NAc), we used in vivo dual-color two-photon imaging. In contrast to other dHPC neurons, the dHPC→NAc subpopulation contained more place cells, with enriched spatial tuning properties. This subpopulation also showed enhanced coding of non-spatial task-relevant behaviors such as deceleration and appetitive licking. A generalized linear model revealed enhanced conjunctive coding in dHPC→NAc neurons which improved the identification of the reward zone. We propose that dHPC routes specific reward-related spatial and behavioral state information to guide NAc action selection.
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650 _ 2 |a Animals
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650 _ 2 |a Mice
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650 _ 2 |a Goals
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650 _ 2 |a Hippocampus
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650 _ 2 |a Appetitive Behavior
|2 MeSH
650 _ 2 |a Spatial Memory
|2 MeSH
650 _ 2 |a Phospholipid Ethers
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650 _ 7 |a 1,2-dihexadecyl-sn-glycero-3-phosphocholine
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650 _ 7 |a Phospholipid Ethers
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700 1 _ |a Mocellin, Petra
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700 1 _ |a Remy, Stefan
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773 _ _ |a 10.1038/s41467-024-47361-x
|g Vol. 15, no. 1, p. 3196
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856 4 _ |u https://pub.dzne.de/record/269033/files/DZNE-2024-00464%20SUP.zip
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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