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000269188 037__ $$aDZNE-2024-00487
000269188 041__ $$aEnglish
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000269188 1001_ $$0P:(DE-2719)2812832$$aKaurani, Lalit$$b0$$eFirst author
000269188 245__ $$aRegulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice.
000269188 260__ $$aHoboken, NJ [u.a.]$$bWiley$$c2024
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000269188 520__ $$aCurrent approaches to the treatment of schizophrenia have mainly focused on the protein-coding part of the genome; in this context, the roles of microRNAs have received less attention. In the present study, we analyze the microRNAome in the blood and postmortem brains of schizophrenia patients, showing that the expression of miR-99b-5p is downregulated in both the prefrontal cortex and blood of patients. Lowering the amount of miR-99b-5p in mice leads to both schizophrenia-like phenotypes and inflammatory processes that are linked to synaptic pruning in microglia. The microglial miR-99b-5p-supressed inflammatory response requires Z-DNA binding protein 1 (Zbp1), which we identify as a novel miR-99b-5p target. Antisense oligonucleotides against Zbp1 ameliorate the pathological effects of miR-99b-5p inhibition. Our findings indicate that a novel miR-99b-5p-Zbp1 pathway in microglia might contribute to the pathogenesis of schizophrenia.
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000269188 650_2 $$2MeSH$$aRNA-Binding Proteins: metabolism
000269188 650_2 $$2MeSH$$aHumans
000269188 650_2 $$2MeSH$$aAnimals
000269188 650_2 $$2MeSH$$aMice
000269188 650_2 $$2MeSH$$aMicroglia: metabolism
000269188 650_2 $$2MeSH$$aSchizophrenia: genetics
000269188 650_2 $$2MeSH$$aMicroRNAs: metabolism
000269188 650_2 $$2MeSH$$aRNA-Binding Proteins
000269188 650_7 $$2NLM Chemicals$$aMirn99 microRNA, mouse
000269188 650_7 $$2Other$$aMicroglia
000269188 650_7 $$2Other$$aSchizophrenia
000269188 650_7 $$2Other$$aZbp1
000269188 650_7 $$2Other$$amiR-99b
000269188 650_7 $$2Other$$amicroRNA
000269188 650_7 $$2NLM Chemicals$$aMicroRNAs
000269188 650_7 $$2NLM Chemicals$$aZbp1 protein, mouse
000269188 650_7 $$2NLM Chemicals$$aRNA-Binding Proteins
000269188 7001_ $$0P:(DE-2719)2811643$$aIslam, Rezaul$$b1$$eFirst author$$udzne
000269188 7001_ $$aHeilbronner, Urs$$b2
000269188 7001_ $$0P:(DE-2719)2812548$$aKrüger, Dennis M$$b3$$udzne
000269188 7001_ $$0P:(DE-2719)9001020$$aZhou, Jiayin$$b4$$udzne
000269188 7001_ $$0P:(DE-2719)9001018$$aMethi, Aditi$$b5$$udzne
000269188 7001_ $$aStrauss, Judith$$b6
000269188 7001_ $$0P:(DE-2719)9001438$$aPradhan, Ranjit$$b7$$udzne
000269188 7001_ $$0P:(DE-2719)9001406$$aSchröder, Sophie$$b8$$udzne
000269188 7001_ $$0P:(DE-2719)2810773$$aBurkhardt, Susanne$$b9$$udzne
000269188 7001_ $$0P:(DE-2719)2810585$$aSchuetz, Anna-Lena$$b10$$udzne
000269188 7001_ $$0P:(DE-2719)2811063$$aPena, Tonatiuh$$b11
000269188 7001_ $$0P:(DE-2719)9000542$$aErlebach, Lena$$b12$$udzne
000269188 7001_ $$0P:(DE-2719)2813030$$aBühler, Anika$$b13$$udzne
000269188 7001_ $$aBudde, Monika$$b14
000269188 7001_ $$aSenner, Fanny$$b15
000269188 7001_ $$aKohshour, Mojtaba Oraki$$b16
000269188 7001_ $$aSchulte, Eva C$$b17
000269188 7001_ $$aSchmauß, Max$$b18
000269188 7001_ $$aReininghaus, Eva Z$$b19
000269188 7001_ $$aJuckel, Georg$$b20
000269188 7001_ $$0P:(DE-2719)9001451$$aKronenberg-Versteeg, Deborah$$b21$$udzne
000269188 7001_ $$aDelalle, Ivana$$b22
000269188 7001_ $$aOdoardi, Francesca$$b23
000269188 7001_ $$aFlügel, Alexander$$b24
000269188 7001_ $$00000-0001-6624-2975$$aSchulze, Thomas G$$b25
000269188 7001_ $$0P:(DE-2719)2811040$$aFalkai, Peter$$b26
000269188 7001_ $$0P:(DE-2719)2811099$$aSananbenesi, Farahnaz$$b27$$udzne
000269188 7001_ $$0P:(DE-2719)2000047$$aFischer, Andre$$b28
000269188 773__ $$0PERI:(DE-600)1467419-1$$a10.1038/s44318-024-00067-8$$gVol. 43, no. 8, p. 1420 - 1444$$n8$$p1420 - 1444$$tThe EMBO journal$$v43$$x0261-4189$$y2024
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