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@ARTICLE{Kaurani:269188,
      author       = {Kaurani, Lalit and Islam, Rezaul and Heilbronner, Urs and
                      Krüger, Dennis M and Zhou, Jiayin and Methi, Aditi and
                      Strauss, Judith and Pradhan, Ranjit and Schröder, Sophie
                      and Burkhardt, Susanne and Schuetz, Anna-Lena and Pena,
                      Tonatiuh and Erlebach, Lena and Bühler, Anika and Budde,
                      Monika and Senner, Fanny and Kohshour, Mojtaba Oraki and
                      Schulte, Eva C and Schmauß, Max and Reininghaus, Eva Z and
                      Juckel, Georg and Kronenberg-Versteeg, Deborah and Delalle,
                      Ivana and Odoardi, Francesca and Flügel, Alexander and
                      Schulze, Thomas G and Falkai, Peter and Sananbenesi,
                      Farahnaz and Fischer, Andre},
      title        = {{R}egulation of {Z}bp1 by mi{R}-99b-5p in microglia
                      controls the development of schizophrenia-like symptoms in
                      mice.},
      journal      = {The EMBO journal},
      volume       = {43},
      number       = {8},
      issn         = {0261-4189},
      address      = {Hoboken, NJ [u.a.]},
      publisher    = {Wiley},
      reportid     = {DZNE-2024-00487},
      pages        = {1420 - 1444},
      year         = {2024},
      abstract     = {Current approaches to the treatment of schizophrenia have
                      mainly focused on the protein-coding part of the genome; in
                      this context, the roles of microRNAs have received less
                      attention. In the present study, we analyze the microRNAome
                      in the blood and postmortem brains of schizophrenia
                      patients, showing that the expression of miR-99b-5p is
                      downregulated in both the prefrontal cortex and blood of
                      patients. Lowering the amount of miR-99b-5p in mice leads to
                      both schizophrenia-like phenotypes and inflammatory
                      processes that are linked to synaptic pruning in microglia.
                      The microglial miR-99b-5p-supressed inflammatory response
                      requires Z-DNA binding protein 1 (Zbp1), which we identify
                      as a novel miR-99b-5p target. Antisense oligonucleotides
                      against Zbp1 ameliorate the pathological effects of
                      miR-99b-5p inhibition. Our findings indicate that a novel
                      miR-99b-5p-Zbp1 pathway in microglia might contribute to the
                      pathogenesis of schizophrenia.},
      keywords     = {RNA-Binding Proteins: metabolism / Humans / Animals / Mice
                      / Microglia: metabolism / Schizophrenia: genetics /
                      MicroRNAs: metabolism / RNA-Binding Proteins / Mirn99
                      microRNA, mouse (NLM Chemicals) / Microglia (Other) /
                      Schizophrenia (Other) / Zbp1 (Other) / miR-99b (Other) /
                      microRNA (Other) / MicroRNAs (NLM Chemicals) / Zbp1 protein,
                      mouse (NLM Chemicals) / RNA-Binding Proteins (NLM
                      Chemicals)},
      cin          = {AG Fischer / AG Kronenberg-Versteeg / AG Jucker},
      ddc          = {570},
      cid          = {I:(DE-2719)1410002 / I:(DE-2719)1210015 /
                      I:(DE-2719)1210001},
      pnm          = {352 - Disease Mechanisms (POF4-352) / 351 - Brain Function
                      (POF4-351)},
      pid          = {G:(DE-HGF)POF4-352 / G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38528182},
      pmc          = {pmc:PMC11021462},
      doi          = {10.1038/s44318-024-00067-8},
      url          = {https://pub.dzne.de/record/269188},
}