guest ::
| Home > Publications Database > Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice. > print |
| Home > Publications Database > Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice. > print |
| 001 | 269188 | ||
| 005 | 20240808164534.0 | ||
| 024 | 7 | _ | |a 10.1038/s44318-024-00067-8 |2 doi |
| 024 | 7 | _ | |a pmid:38528182 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC11021462 |2 pmc |
| 024 | 7 | _ | |a 0261-4189 |2 ISSN |
| 024 | 7 | _ | |a 1460-2075 |2 ISSN |
| 024 | 7 | _ | |a altmetric:161180588 |2 altmetric |
| 037 | _ | _ | |a DZNE-2024-00487 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Kaurani, Lalit |0 P:(DE-2719)2812832 |b 0 |e First author |
| 245 | _ | _ | |a Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice. |
| 260 | _ | _ | |a Hoboken, NJ [u.a.] |c 2024 |b Wiley |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1713865687_10932 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Current approaches to the treatment of schizophrenia have mainly focused on the protein-coding part of the genome; in this context, the roles of microRNAs have received less attention. In the present study, we analyze the microRNAome in the blood and postmortem brains of schizophrenia patients, showing that the expression of miR-99b-5p is downregulated in both the prefrontal cortex and blood of patients. Lowering the amount of miR-99b-5p in mice leads to both schizophrenia-like phenotypes and inflammatory processes that are linked to synaptic pruning in microglia. The microglial miR-99b-5p-supressed inflammatory response requires Z-DNA binding protein 1 (Zbp1), which we identify as a novel miR-99b-5p target. Antisense oligonucleotides against Zbp1 ameliorate the pathological effects of miR-99b-5p inhibition. Our findings indicate that a novel miR-99b-5p-Zbp1 pathway in microglia might contribute to the pathogenesis of schizophrenia. |
| 536 | _ | _ | |a 352 - Disease Mechanisms (POF4-352) |0 G:(DE-HGF)POF4-352 |c POF4-352 |f POF IV |x 0 |
| 536 | _ | _ | |a 351 - Brain Function (POF4-351) |0 G:(DE-HGF)POF4-351 |c POF4-351 |f POF IV |x 1 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 2 | |a RNA-Binding Proteins: metabolism |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Microglia: metabolism |2 MeSH |
| 650 | _ | 2 | |a Schizophrenia: genetics |2 MeSH |
| 650 | _ | 2 | |a MicroRNAs: metabolism |2 MeSH |
| 650 | _ | 2 | |a RNA-Binding Proteins |2 MeSH |
| 650 | _ | 7 | |a Mirn99 microRNA, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Microglia |2 Other |
| 650 | _ | 7 | |a Schizophrenia |2 Other |
| 650 | _ | 7 | |a Zbp1 |2 Other |
| 650 | _ | 7 | |a miR-99b |2 Other |
| 650 | _ | 7 | |a microRNA |2 Other |
| 650 | _ | 7 | |a MicroRNAs |2 NLM Chemicals |
| 650 | _ | 7 | |a Zbp1 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a RNA-Binding Proteins |2 NLM Chemicals |
| 700 | 1 | _ | |a Islam, Rezaul |0 P:(DE-2719)2811643 |b 1 |e First author |u dzne |
| 700 | 1 | _ | |a Heilbronner, Urs |b 2 |
| 700 | 1 | _ | |a Krüger, Dennis M |0 P:(DE-2719)2812548 |b 3 |u dzne |
| 700 | 1 | _ | |a Zhou, Jiayin |0 P:(DE-2719)9001020 |b 4 |u dzne |
| 700 | 1 | _ | |a Methi, Aditi |0 P:(DE-2719)9001018 |b 5 |u dzne |
| 700 | 1 | _ | |a Strauss, Judith |b 6 |
| 700 | 1 | _ | |a Pradhan, Ranjit |0 P:(DE-2719)9001438 |b 7 |u dzne |
| 700 | 1 | _ | |a Schröder, Sophie |0 P:(DE-2719)9001406 |b 8 |u dzne |
| 700 | 1 | _ | |a Burkhardt, Susanne |0 P:(DE-2719)2810773 |b 9 |u dzne |
| 700 | 1 | _ | |a Schuetz, Anna-Lena |0 P:(DE-2719)2810585 |b 10 |u dzne |
| 700 | 1 | _ | |a Pena, Tonatiuh |0 P:(DE-2719)2811063 |b 11 |
| 700 | 1 | _ | |a Erlebach, Lena |0 P:(DE-2719)9000542 |b 12 |u dzne |
| 700 | 1 | _ | |a Bühler, Anika |0 P:(DE-2719)2813030 |b 13 |u dzne |
| 700 | 1 | _ | |a Budde, Monika |b 14 |
| 700 | 1 | _ | |a Senner, Fanny |b 15 |
| 700 | 1 | _ | |a Kohshour, Mojtaba Oraki |b 16 |
| 700 | 1 | _ | |a Schulte, Eva C |b 17 |
| 700 | 1 | _ | |a Schmauß, Max |b 18 |
| 700 | 1 | _ | |a Reininghaus, Eva Z |b 19 |
| 700 | 1 | _ | |a Juckel, Georg |b 20 |
| 700 | 1 | _ | |a Kronenberg-Versteeg, Deborah |0 P:(DE-2719)9001451 |b 21 |u dzne |
| 700 | 1 | _ | |a Delalle, Ivana |b 22 |
| 700 | 1 | _ | |a Odoardi, Francesca |b 23 |
| 700 | 1 | _ | |a Flügel, Alexander |b 24 |
| 700 | 1 | _ | |a Schulze, Thomas G |0 0000-0001-6624-2975 |b 25 |
| 700 | 1 | _ | |a Falkai, Peter |0 P:(DE-2719)2811040 |b 26 |
| 700 | 1 | _ | |a Sananbenesi, Farahnaz |0 P:(DE-2719)2811099 |b 27 |u dzne |
| 700 | 1 | _ | |a Fischer, Andre |0 P:(DE-2719)2000047 |b 28 |
| 773 | _ | _ | |a 10.1038/s44318-024-00067-8 |g Vol. 43, no. 8, p. 1420 - 1444 |0 PERI:(DE-600)1467419-1 |n 8 |p 1420 - 1444 |t The EMBO journal |v 43 |y 2024 |x 0261-4189 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/269188/files/DZNE-2024-00487%20SUP.zip |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/269188/files/DZNE-2024-00487.pdf |
| 856 | 4 | _ | |y OpenAccess |x pdfa |u https://pub.dzne.de/record/269188/files/DZNE-2024-00487.pdf?subformat=pdfa |
| 909 | C | O | |o oai:pub.dzne.de:269188 |p openaire |p open_access |p VDB |p driver |p dnbdelivery |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 0 |6 P:(DE-2719)2812832 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 1 |6 P:(DE-2719)2811643 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 3 |6 P:(DE-2719)2812548 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 4 |6 P:(DE-2719)9001020 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 5 |6 P:(DE-2719)9001018 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 7 |6 P:(DE-2719)9001438 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 8 |6 P:(DE-2719)9001406 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 9 |6 P:(DE-2719)2810773 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 10 |6 P:(DE-2719)2810585 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 11 |6 P:(DE-2719)2811063 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 12 |6 P:(DE-2719)9000542 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 13 |6 P:(DE-2719)2813030 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 21 |6 P:(DE-2719)9001451 |
| 910 | 1 | _ | |a External Institute |0 I:(DE-HGF)0 |k Extern |b 27 |6 P:(DE-2719)2811099 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 28 |6 P:(DE-2719)2000047 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-352 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Disease Mechanisms |x 0 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-351 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Brain Function |x 1 |
| 914 | 1 | _ | |y 2024 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2023-08-24 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b EMBO J : 2022 |d 2023-08-24 |
| 915 | _ | _ | |a IF >= 10 |0 StatID:(DE-HGF)9910 |2 StatID |b EMBO J : 2022 |d 2023-08-24 |
| 915 | _ | _ | |a DEAL Wiley |0 StatID:(DE-HGF)3001 |2 StatID |d 2023-08-24 |w ger |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2023-08-24 |
| 915 | _ | _ | |a Creative Commons Attribution CC BY 4.0 |0 LIC:(DE-HGF)CCBY4 |2 HGFVOC |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0320 |2 StatID |b PubMed Central |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2023-08-24 |
| 920 | 1 | _ | |0 I:(DE-2719)1410002 |k AG Fischer |l Epigenetics and Systems Medicine in Neurodegenerative Diseases |x 0 |
| 920 | 1 | _ | |0 I:(DE-2719)1210015 |k AG Kronenberg-Versteeg |l Glial Cell Biology |x 1 |
| 920 | 1 | _ | |0 I:(DE-2719)1210001 |k AG Jucker |l Cell Biology of Neurological Diseases |x 2 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a I:(DE-2719)1410002 |
| 980 | _ | _ | |a I:(DE-2719)1210015 |
| 980 | _ | _ | |a I:(DE-2719)1210001 |
| 980 | 1 | _ | |a FullTexts |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|