%0 Journal Article
%A Endres, Dominique
%A von Zedtwitz, Katharina
%A Nickel, Kathrin
%A Runge, Kimon
%A Maier, Alexander
%A Domschke, Katharina
%A Salzer, Ulrich
%A Prüss, Harald
%A Venhoff, Nils
%A van Elst, Ludger Tebartz
%T Association of rheumatological markers with neuronal antibodies, cerebrospinal fluid, electroencephalography, and magnetic resonance imaging findings in 224 patients with psychotic syndromes
%J Brain, behavior and immunity
%V 119
%@ 0889-1591
%C Orlando, Fla.
%I Academic Press
%M DZNE-2024-00509
%P 482 - 493
%D 2024
%X Psychotic syndromes can have autoimmune-mediated causes in some patients. Thus, this retrospective work aims to investigate the role of rheumatological markers in the development of psychosis.In total, 224 patients with psychotic syndromes receiving a 'rheumatological laboratory screening' (including C-reactive protein [CRP], immunofixation, complement factors, rheumatoid factor [RF], antiphospholipid antibodies [APAs], antineutrophil cytoplasmic antibodies [ANCAs], and antinuclear antibodies [ANAs]) were analyzed. A further diagnostic work-up included investigations of neuronal antibodies and cerebrospinal fluid (CSF), as well as electroencephalography (EEG) and magnetic resonance imaging (MRI) of the brain. ANA testing was routinely performed in all patients using serum on human epithelioma-2 (Hep2) cells, and a subset of patients (N = 73) also underwent tissue-based assays from serum and CSF. The number of cases with autoimmune psychotic syndromes was descriptively collected, and ANA-positive and -negative patients were compared in detail.CRP was elevated in 9 
%K Humans
%K Psychotic Disorders: immunology
%K Male
%K Female
%K Adult
%K Electroencephalography: methods
%K Middle Aged
%K Magnetic Resonance Imaging: methods
%K Retrospective Studies
%K Biomarkers: cerebrospinal fluid
%K Biomarkers: blood
%K C-Reactive Protein: analysis
%K C-Reactive Protein: metabolism
%K Autoantibodies: cerebrospinal fluid
%K Autoantibodies: blood
%K Antibodies, Antinuclear: cerebrospinal fluid
%K Aged
%K Brain: diagnostic imaging
%K Brain: metabolism
%K Young Adult
%K Autoimmune Diseases: cerebrospinal fluid
%K Neurons: metabolism
%K Adolescent
%K Rheumatic Diseases: cerebrospinal fluid
%K ANA (Other)
%K Antibody (Other)
%K Autoimmune psychosis (Other)
%K Complement (Other)
%K Immunological (Other)
%K Biomarkers (NLM Chemicals)
%K C-Reactive Protein (NLM Chemicals)
%K Autoantibodies (NLM Chemicals)
%K Antibodies, Antinuclear (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38599500
%R 10.1016/j.bbi.2024.04.001
%U https://pub.dzne.de/record/269340