TY  - JOUR
AU  - Endres, Dominique
AU  - von Zedtwitz, Katharina
AU  - Nickel, Kathrin
AU  - Runge, Kimon
AU  - Maier, Alexander
AU  - Domschke, Katharina
AU  - Salzer, Ulrich
AU  - Prüss, Harald
AU  - Venhoff, Nils
AU  - van Elst, Ludger Tebartz
TI  - Association of rheumatological markers with neuronal antibodies, cerebrospinal fluid, electroencephalography, and magnetic resonance imaging findings in 224 patients with psychotic syndromes
JO  - Brain, behavior and immunity
VL  - 119
SN  - 0889-1591
CY  - Orlando, Fla.
PB  - Academic Press
M1  - DZNE-2024-00509
SP  - 482 - 493
PY  - 2024
AB  - Psychotic syndromes can have autoimmune-mediated causes in some patients. Thus, this retrospective work aims to investigate the role of rheumatological markers in the development of psychosis.In total, 224 patients with psychotic syndromes receiving a 'rheumatological laboratory screening' (including C-reactive protein [CRP], immunofixation, complement factors, rheumatoid factor [RF], antiphospholipid antibodies [APAs], antineutrophil cytoplasmic antibodies [ANCAs], and antinuclear antibodies [ANAs]) were analyzed. A further diagnostic work-up included investigations of neuronal antibodies and cerebrospinal fluid (CSF), as well as electroencephalography (EEG) and magnetic resonance imaging (MRI) of the brain. ANA testing was routinely performed in all patients using serum on human epithelioma-2 (Hep2) cells, and a subset of patients (N = 73) also underwent tissue-based assays from serum and CSF. The number of cases with autoimmune psychotic syndromes was descriptively collected, and ANA-positive and -negative patients were compared in detail.CRP was elevated in 9 
KW  - Humans
KW  - Psychotic Disorders: immunology
KW  - Male
KW  - Female
KW  - Adult
KW  - Electroencephalography: methods
KW  - Middle Aged
KW  - Magnetic Resonance Imaging: methods
KW  - Retrospective Studies
KW  - Biomarkers: cerebrospinal fluid
KW  - Biomarkers: blood
KW  - C-Reactive Protein: analysis
KW  - C-Reactive Protein: metabolism
KW  - Autoantibodies: cerebrospinal fluid
KW  - Autoantibodies: blood
KW  - Antibodies, Antinuclear: cerebrospinal fluid
KW  - Aged
KW  - Brain: diagnostic imaging
KW  - Brain: metabolism
KW  - Young Adult
KW  - Autoimmune Diseases: cerebrospinal fluid
KW  - Neurons: metabolism
KW  - Adolescent
KW  - Rheumatic Diseases: cerebrospinal fluid
KW  - ANA (Other)
KW  - Antibody (Other)
KW  - Autoimmune psychosis (Other)
KW  - Complement (Other)
KW  - Immunological (Other)
KW  - Biomarkers (NLM Chemicals)
KW  - C-Reactive Protein (NLM Chemicals)
KW  - Autoantibodies (NLM Chemicals)
KW  - Antibodies, Antinuclear (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:38599500
DO  - DOI:10.1016/j.bbi.2024.04.001
UR  - https://pub.dzne.de/record/269340
ER  -