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000269358 1001_ $$0P:(DE-2719)9001827$$aLiebscher, Maxie$$b0$$eFirst author$$udzne
000269358 245__ $$aShort communication: Lifetime musical activity and resting-state functional connectivity in cognitive networks.
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000269358 520__ $$aParticipation in multimodal leisure activities, such as playing a musical instrument, may be protective against brain aging and dementia in older adults (OA). Potential neuroprotective correlates underlying musical activity remain unclear.This cross-sectional study investigated the association between lifetime musical activity and resting-state functional connectivity (RSFC) in three higher-order brain networks: the Default Mode, Fronto-Parietal, and Salience networks.We assessed 130 cognitively unimpaired participants (≥ 60 years) from the baseline cohort of the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Lifetime musical activity was operationalized by the self-reported participation in musical instrument playing across early, middle, and late life stages using the Lifetime of Experiences Questionnaire (LEQ). Participants who reported musical activity during all life stages (n = 65) were compared to controls who were matched on demographic and reserve characteristics (including education, intelligence, socioeconomic status, self-reported physical activity, age, and sex) and never played a musical instrument (n = 65) in local (seed-to-voxel) and global (within-network and between-network) RSFC patterns using pre-specified network seeds.Older participants with lifetime musical activity showed significantly higher local RSFC between the medial prefrontal cortex (Default Mode Network seed) and temporal as well as frontal regions, namely the right temporal pole and the right precentral gyrus extending into the superior frontal gyrus, compared to matched controls. There were no significant group differences in global RSFC within or between the three networks.We show that playing a musical instrument during life relates to higher RSFC of the medial prefrontal cortex with distant brain regions involved in higher-order cognitive and motor processes. Preserved or enhanced functional connectivity could potentially contribute to better brain health and resilience in OA with a history in musical activity.German Clinical Trials Register (DRKS00007966, 04/05/2015).
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000269358 650_2 $$2MeSH$$aHumans
000269358 650_2 $$2MeSH$$aMusic
000269358 650_2 $$2MeSH$$aMale
000269358 650_2 $$2MeSH$$aFemale
000269358 650_2 $$2MeSH$$aAged
000269358 650_2 $$2MeSH$$aMiddle Aged
000269358 650_2 $$2MeSH$$aCognition: physiology
000269358 650_2 $$2MeSH$$aCross-Sectional Studies
000269358 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000269358 650_2 $$2MeSH$$aNerve Net: physiology
000269358 650_2 $$2MeSH$$aNerve Net: diagnostic imaging
000269358 650_2 $$2MeSH$$aBrain: physiology
000269358 650_2 $$2MeSH$$aBrain: diagnostic imaging
000269358 693__ $$0EXP:(DE-2719)DELCODE-20140101$$5EXP:(DE-2719)DELCODE-20140101$$eLongitudinal Cognitive Impairment and Dementia Study$$x0
000269358 7001_ $$0P:(DE-2719)9001684$$aDell'Orco, Andrea$$b1
000269358 7001_ $$aDoll-Lee, Johanna$$b2
000269358 7001_ $$0P:(DE-2719)2811351$$aBuerger, Katharina$$b3$$udzne
000269358 7001_ $$aDechent, Peter$$b4
000269358 7001_ $$0P:(DE-2719)9000543$$aEwers, Michael$$b5$$udzne
000269358 7001_ $$0P:(DE-2719)2811326$$aFliessbach, Klaus$$b6$$udzne
000269358 7001_ $$0P:(DE-2719)2811614$$aGlanz, Wenzel$$b7$$udzne
000269358 7001_ $$aHetzer, Stefan$$b8
000269358 7001_ $$0P:(DE-2719)9002557$$aJanowitz, Daniel$$b9$$udzne
000269358 7001_ $$0P:(DE-2719)2810394$$aKilimann, Ingo$$b10$$udzne
000269358 7001_ $$0P:(DE-2719)2000055$$aLaske, Christoph$$b11$$udzne
000269358 7001_ $$0P:(DE-HGF)0$$aLüsebrink, Falk$$b12
000269358 7001_ $$0P:(DE-2719)9001516$$aMunk, Matthias$$b13$$udzne
000269358 7001_ $$0P:(DE-2719)2812234$$aPerneczky, Robert$$b14$$udzne
000269358 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b15$$udzne
000269358 7001_ $$0P:(DE-2719)9000703$$aPreis, Lukas$$b16$$udzne
000269358 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b17$$udzne
000269358 7001_ $$0P:(DE-2719)9001808$$aRauchmann, Boris Stephan$$b18$$udzne
000269358 7001_ $$aRostamzadeh, Ayda$$b19
000269358 7001_ $$0P:(DE-2719)2812341$$aRoy-Kluth, Nina$$b20$$udzne
000269358 7001_ $$aScheffler, Klaus$$b21
000269358 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b22$$udzne
000269358 7001_ $$0P:(DE-2719)2814326$$aSchott, Björn H$$b23
000269358 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b24$$udzne
000269358 7001_ $$0P:(DE-2719)2812446$$aSpruth, Eike Jakob$$b25
000269358 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b26$$udzne
000269358 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b27$$udzne
000269358 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b28$$udzne
000269358 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b29$$udzne
000269358 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b30$$udzne
000269358 7001_ $$0P:(DE-2719)2810395$$aRöske, Sandra$$b31$$udzne
000269358 7001_ $$0P:(DE-2719)2814122$$aWirth, Miranka$$b32$$eLast author$$udzne
000269358 7001_ $$agroup, DELCODE study$$b33$$eCollaboration Author
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