TY  - JOUR
AU  - Liebscher, Maxie
AU  - Dell'Orco, Andrea
AU  - Doll-Lee, Johanna
AU  - Buerger, Katharina
AU  - Dechent, Peter
AU  - Ewers, Michael
AU  - Fliessbach, Klaus
AU  - Glanz, Wenzel
AU  - Hetzer, Stefan
AU  - Janowitz, Daniel
AU  - Kilimann, Ingo
AU  - Laske, Christoph
AU  - Lüsebrink, Falk
AU  - Munk, Matthias
AU  - Perneczky, Robert
AU  - Peters, Oliver
AU  - Preis, Lukas
AU  - Priller, Josef
AU  - Rauchmann, Boris Stephan
AU  - Rostamzadeh, Ayda
AU  - Roy-Kluth, Nina
AU  - Scheffler, Klaus
AU  - Schneider, Anja
AU  - Schott, Björn H
AU  - Spottke, Annika
AU  - Spruth, Eike Jakob
AU  - Teipel, Stefan
AU  - Wiltfang, Jens
AU  - Jessen, Frank
AU  - Düzel, Emrah
AU  - Wagner, Michael
AU  - Röske, Sandra
AU  - Wirth, Miranka
TI  - Short communication: Lifetime musical activity and resting-state functional connectivity in cognitive networks.
JO  - PLOS ONE
VL  - 19
IS  - 5
SN  - 1932-6203
CY  - San Francisco, California, US
PB  - PLOS
M1  - DZNE-2024-00526
SP  - e0299939
PY  - 2024
AB  - Participation in multimodal leisure activities, such as playing a musical instrument, may be protective against brain aging and dementia in older adults (OA). Potential neuroprotective correlates underlying musical activity remain unclear.This cross-sectional study investigated the association between lifetime musical activity and resting-state functional connectivity (RSFC) in three higher-order brain networks: the Default Mode, Fronto-Parietal, and Salience networks.We assessed 130 cognitively unimpaired participants (≥ 60 years) from the baseline cohort of the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Lifetime musical activity was operationalized by the self-reported participation in musical instrument playing across early, middle, and late life stages using the Lifetime of Experiences Questionnaire (LEQ). Participants who reported musical activity during all life stages (n = 65) were compared to controls who were matched on demographic and reserve characteristics (including education, intelligence, socioeconomic status, self-reported physical activity, age, and sex) and never played a musical instrument (n = 65) in local (seed-to-voxel) and global (within-network and between-network) RSFC patterns using pre-specified network seeds.Older participants with lifetime musical activity showed significantly higher local RSFC between the medial prefrontal cortex (Default Mode Network seed) and temporal as well as frontal regions, namely the right temporal pole and the right precentral gyrus extending into the superior frontal gyrus, compared to matched controls. There were no significant group differences in global RSFC within or between the three networks.We show that playing a musical instrument during life relates to higher RSFC of the medial prefrontal cortex with distant brain regions involved in higher-order cognitive and motor processes. Preserved or enhanced functional connectivity could potentially contribute to better brain health and resilience in OA with a history in musical activity.German Clinical Trials Register (DRKS00007966, 04/05/2015).
KW  - Humans
KW  - Music
KW  - Male
KW  - Female
KW  - Aged
KW  - Middle Aged
KW  - Cognition: physiology
KW  - Cross-Sectional Studies
KW  - Magnetic Resonance Imaging
KW  - Nerve Net: physiology
KW  - Nerve Net: diagnostic imaging
KW  - Brain: physiology
KW  - Brain: diagnostic imaging
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC11065262
C6  - pmid:38696395
DO  - DOI:10.1371/journal.pone.0299939
UR  - https://pub.dzne.de/record/269358
ER  -