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@ARTICLE{Liebscher:269358,
      author       = {Liebscher, Maxie and Dell'Orco, Andrea and Doll-Lee,
                      Johanna and Buerger, Katharina and Dechent, Peter and Ewers,
                      Michael and Fliessbach, Klaus and Glanz, Wenzel and Hetzer,
                      Stefan and Janowitz, Daniel and Kilimann, Ingo and Laske,
                      Christoph and Lüsebrink, Falk and Munk, Matthias and
                      Perneczky, Robert and Peters, Oliver and Preis, Lukas and
                      Priller, Josef and Rauchmann, Boris Stephan and Rostamzadeh,
                      Ayda and Roy-Kluth, Nina and Scheffler, Klaus and Schneider,
                      Anja and Schott, Björn H and Spottke, Annika and Spruth,
                      Eike Jakob and Teipel, Stefan and Wiltfang, Jens and Jessen,
                      Frank and Düzel, Emrah and Wagner, Michael and Röske,
                      Sandra and Wirth, Miranka},
      collaboration = {group, DELCODE study},
      title        = {{S}hort communication: {L}ifetime musical activity and
                      resting-state functional connectivity in cognitive
                      networks.},
      journal      = {PLOS ONE},
      volume       = {19},
      number       = {5},
      issn         = {1932-6203},
      address      = {San Francisco, California, US},
      publisher    = {PLOS},
      reportid     = {DZNE-2024-00526},
      pages        = {e0299939},
      year         = {2024},
      abstract     = {Participation in multimodal leisure activities, such as
                      playing a musical instrument, may be protective against
                      brain aging and dementia in older adults (OA). Potential
                      neuroprotective correlates underlying musical activity
                      remain unclear.This cross-sectional study investigated the
                      association between lifetime musical activity and
                      resting-state functional connectivity (RSFC) in three
                      higher-order brain networks: the Default Mode,
                      Fronto-Parietal, and Salience networks.We assessed 130
                      cognitively unimpaired participants (≥ 60 years) from the
                      baseline cohort of the DZNE-Longitudinal Cognitive
                      Impairment and Dementia Study (DELCODE) study. Lifetime
                      musical activity was operationalized by the self-reported
                      participation in musical instrument playing across early,
                      middle, and late life stages using the Lifetime of
                      Experiences Questionnaire (LEQ). Participants who reported
                      musical activity during all life stages (n = 65) were
                      compared to controls who were matched on demographic and
                      reserve characteristics (including education, intelligence,
                      socioeconomic status, self-reported physical activity, age,
                      and sex) and never played a musical instrument (n = 65) in
                      local (seed-to-voxel) and global (within-network and
                      between-network) RSFC patterns using pre-specified network
                      seeds.Older participants with lifetime musical activity
                      showed significantly higher local RSFC between the medial
                      prefrontal cortex (Default Mode Network seed) and temporal
                      as well as frontal regions, namely the right temporal pole
                      and the right precentral gyrus extending into the superior
                      frontal gyrus, compared to matched controls. There were no
                      significant group differences in global RSFC within or
                      between the three networks.We show that playing a musical
                      instrument during life relates to higher RSFC of the medial
                      prefrontal cortex with distant brain regions involved in
                      higher-order cognitive and motor processes. Preserved or
                      enhanced functional connectivity could potentially
                      contribute to better brain health and resilience in OA with
                      a history in musical activity.German Clinical Trials
                      Register (DRKS00007966, 04/05/2015).},
      keywords     = {Humans / Music / Male / Female / Aged / Middle Aged /
                      Cognition: physiology / Cross-Sectional Studies / Magnetic
                      Resonance Imaging / Nerve Net: physiology / Nerve Net:
                      diagnostic imaging / Brain: physiology / Brain: diagnostic
                      imaging},
      cin          = {AG Wirth / AG Wagner / AG Spottke / Clinical Research
                      (Munich) / Patient Studies Bonn / AG Dichgans / AG Schneider
                      / AG Fischer / AG Düzel / AG Teipel / AG Gasser / AG Peters
                      / AG Priller / AG Wiltfang / AG Jessen},
      ddc          = {610},
      cid          = {I:(DE-2719)1710011 / I:(DE-2719)1011201 /
                      I:(DE-2719)1011103 / I:(DE-2719)1111015 / I:(DE-2719)1011101
                      / I:(DE-2719)5000022 / I:(DE-2719)1011305 /
                      I:(DE-2719)1410002 / I:(DE-2719)5000006 / I:(DE-2719)1510100
                      / I:(DE-2719)1210000 / I:(DE-2719)5000000 /
                      I:(DE-2719)5000007 / I:(DE-2719)1410006 /
                      I:(DE-2719)1011102},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 352 -
                      Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-352},
      experiment   = {EXP:(DE-2719)DELCODE-20140101},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC11065262},
      pubmed       = {pmid:38696395},
      doi          = {10.1371/journal.pone.0299939},
      url          = {https://pub.dzne.de/record/269358},
}