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000269432 037__ $$aDZNE-2024-00529
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000269432 1001_ $$aChelini, Gabriele$$b0
000269432 245__ $$aFocal clusters of peri-synaptic matrix contribute to activity-dependent plasticity and memory in mice
000269432 260__ $$a[New York, NY]$$bElsevier$$c2024
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000269432 520__ $$aRecent findings show that effective integration of novel information in the brain requires coordinated processes of homo- and heterosynaptic plasticity. In this work, we hypothesize that activity-dependent remodeling of the peri-synaptic extracellular matrix (ECM) contributes to these processes. We show that clusters of the peri-synaptic ECM, recognized by CS56 antibody, emerge in response to sensory stimuli, showing temporal and spatial coincidence with dendritic spine plasticity. Using CS56 co-immunoprecipitation of synaptosomal proteins, we identify several molecules involved in Ca2+ signaling, vesicle cycling, and AMPA-receptor exocytosis, thus suggesting a role in long-term potentiation (LTP). Finally, we show that, in the CA1 hippocampal region, the attenuation of CS56 glycoepitopes, through the depletion of versican as one of its main carriers, impairs LTP and object location memory in mice. These findings show that activity-dependent remodeling of the peri-synaptic ECM regulates the induction and consolidation of LTP, contributing to hippocampal-dependent memory.
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000269432 650_7 $$2Other$$aCP: Cell biology
000269432 650_7 $$2Other$$aCP: Neuroscience
000269432 650_7 $$2Other$$aCS clusters
000269432 650_7 $$2Other$$achondrotin sulfate proteoglycans
000269432 650_7 $$2Other$$aextracellular matrix
000269432 650_7 $$2Other$$ahippocampus
000269432 650_7 $$2Other$$aimmunoprecipitation
000269432 650_7 $$2Other$$alearning and memory
000269432 650_7 $$2Other$$asensory manipulation
000269432 650_7 $$2Other$$asynaptic plasticity
000269432 650_7 $$2Other$$aversican
000269432 650_2 $$2MeSH$$aAnimals
000269432 650_2 $$2MeSH$$aExtracellular Matrix: metabolism
000269432 650_2 $$2MeSH$$aLong-Term Potentiation: physiology
000269432 650_2 $$2MeSH$$aMice
000269432 650_2 $$2MeSH$$aNeuronal Plasticity: physiology
000269432 650_2 $$2MeSH$$aMemory: physiology
000269432 650_2 $$2MeSH$$aSynapses: metabolism
000269432 650_2 $$2MeSH$$aSynapses: physiology
000269432 650_2 $$2MeSH$$aMice, Inbred C57BL
000269432 650_2 $$2MeSH$$aMale
000269432 650_2 $$2MeSH$$aCA1 Region, Hippocampal: metabolism
000269432 650_2 $$2MeSH$$aCA1 Region, Hippocampal: physiology
000269432 650_2 $$2MeSH$$aCA1 Region, Hippocampal: cytology
000269432 650_2 $$2MeSH$$aHippocampus: metabolism
000269432 650_2 $$2MeSH$$aHippocampus: physiology
000269432 7001_ $$0P:(DE-2719)2814120$$aMirzapourdelavar, Hadi$$b1$$udzne
000269432 7001_ $$aDurning, Peter$$b2
000269432 7001_ $$0P:(DE-2719)9001469$$aBaidoe-Ansah, David$$b3$$udzne
000269432 7001_ $$aSethi, Manveen K.$$b4
000269432 7001_ $$aO’Donovan, Sinead M.$$b5
000269432 7001_ $$aKlengel, Torsten$$b6
000269432 7001_ $$aBalasco, Luigi$$b7
000269432 7001_ $$aBerciu, Cristina$$b8
000269432 7001_ $$aBoyer-Boiteau, Anne$$b9
000269432 7001_ $$aMcCullumsmith, Robert$$b10
000269432 7001_ $$aRessler, Kerry J.$$b11
000269432 7001_ $$aZaia, Joseph$$b12
000269432 7001_ $$aBozzi, Yuri$$b13
000269432 7001_ $$0P:(DE-2719)2810577$$aDityatev, Alexander$$b14$$udzne
000269432 7001_ $$00000-0002-4057-7766$$aBerretta, Sabina$$b15
000269432 773__ $$0PERI:(DE-600)2649101-1$$a10.1016/j.celrep.2024.114112$$gVol. 43, no. 5, p. 114112 -$$n5$$p114112$$tCell reports$$v43$$x2211-1247$$y2024
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