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@ARTICLE{Deng:269441,
      author       = {Deng, Yushuang and Kumar, Avadh and Xie, Kan and Schaaf,
                      Kristina and Scifo, Enzo and Morsy, Sarah and Li, Tao and
                      Ehninger, Armin and Bano, Daniele and Ehninger, Dan},
      title        = {{T}argeting senescent cells with {NKG}2{D}-{CAR} {T}
                      cells.},
      journal      = {Cell death discovery},
      volume       = {10},
      number       = {1},
      issn         = {2058-7716},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {DZNE-2024-00538},
      pages        = {217},
      year         = {2024},
      abstract     = {This study investigates the efficacy of NKG2D chimeric
                      antigen receptor (CAR) engineered T cells in targeting and
                      eliminating stress-induced senescent cells in vitro.
                      Cellular senescence contributes to age-related tissue
                      decline and is characterized by permanent cell cycle arrest
                      and the senescence-associated secretory phenotype (SASP).
                      Immunotherapy, particularly CAR-T cell therapy, emerges as a
                      promising approach to selectively eliminate senescent cells.
                      Our focus is on the NKG2D receptor, which binds to ligands
                      (NKG2DLs) upregulated in senescent cells, offering a target
                      for CAR-T cells. Using mouse embryonic fibroblasts (MEFs)
                      and astrocytes (AST) as senescence models, we demonstrate
                      the elevated expression of NKG2DLs in response to genotoxic
                      and oxidative stress. NKG2D-CAR T cells displayed potent
                      cytotoxicity against these senescent cells, with minimal
                      effects on non-senescent cells, suggesting their potential
                      as targeted senolytics. In conclusion, our research presents
                      the first evidence of NKG2D-CAR T cells' ability to target
                      senescent brain cells, offering a novel approach to manage
                      senescence-associated diseases. The findings pave the way
                      for future investigations into the therapeutic applicability
                      of NKG2D-targeting CAR-T cells in naturally aged organisms
                      and models of aging-associated brain diseases in vivo.},
      cin          = {AG Ehninger / AG Bano},
      ddc          = {610},
      cid          = {I:(DE-2719)1013005 / I:(DE-2719)1013003},
      pnm          = {352 - Disease Mechanisms (POF4-352) / 351 - Brain Function
                      (POF4-351)},
      pid          = {G:(DE-HGF)POF4-352 / G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38704364},
      pmc          = {pmc:PMC11069534},
      doi          = {10.1038/s41420-024-01976-7},
      url          = {https://pub.dzne.de/record/269441},
}