000269530 001__ 269530
000269530 005__ 20240808164512.0
000269530 0247_ $$2pmc$$apmc:PMC11128282
000269530 0247_ $$2doi$$a10.1242/jcs.261512
000269530 0247_ $$2pmid$$apmid:38587100
000269530 0247_ $$2ISSN$$a0370-2952
000269530 0247_ $$2ISSN$$a0021-9533
000269530 0247_ $$2ISSN$$a1477-9137
000269530 0247_ $$2altmetric$$aaltmetric:161669442
000269530 037__ $$aDZNE-2024-00571
000269530 041__ $$aEnglish
000269530 082__ $$a570
000269530 1001_ $$0P:(DE-2719)9000868$$aZhang, Yun$$b0$$eFirst author
000269530 245__ $$aAugmin complex activity finetunes dendrite morphology through non-centrosomal microtubule nucleation in vivo.
000269530 260__ $$aCambridge$$bCompany of Biologists Limited$$c2024
000269530 3367_ $$2DRIVER$$aarticle
000269530 3367_ $$2DataCite$$aOutput Types/Journal article
000269530 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1715679396_2121
000269530 3367_ $$2BibTeX$$aARTICLE
000269530 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000269530 3367_ $$00$$2EndNote$$aJournal Article
000269530 520__ $$aDuring development, neurons achieve a stereotyped neuron type-specific morphology, which relies on dynamic support by microtubules (MTs). An important player is the augmin complex (hereafter augmin), which binds to existing MT filaments and recruits the γ-tubulin ring complex (γ-TuRC), to form branched MTs. In cultured neurons, augmin is important for neurite formation. However, little is known about the role of augmin during neurite formation in vivo. Here, we have revisited the role of mammalian augmin in culture and then turned towards the class four Drosophila dendritic arborization (c4da) neurons. We show that MT density is maintained through augmin in cooperation with the γ-TuRC in vivo. Mutant c4da neurons show a reduction of newly emerging higher-order dendritic branches and in turn also a reduced number of their characteristic space-filling higher-order branchlets. Taken together, our data reveal a cooperative function for augmin with the γ-TuRC in forming enough MTs needed for the appropriate differentiation of morphologically complex dendrites in vivo.
000269530 536__ $$0G:(DE-HGF)POF4-351$$a351 - Brain Function (POF4-351)$$cPOF4-351$$fPOF IV$$x0
000269530 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000269530 650_2 $$2MeSH$$aAnimals
000269530 650_2 $$2MeSH$$aMicrotubules: metabolism
000269530 650_2 $$2MeSH$$aDendrites: metabolism
000269530 650_2 $$2MeSH$$aDrosophila Proteins: metabolism
000269530 650_2 $$2MeSH$$aDrosophila Proteins: genetics
000269530 650_2 $$2MeSH$$aMicrotubule-Associated Proteins: metabolism
000269530 650_2 $$2MeSH$$aMicrotubule-Associated Proteins: genetics
000269530 650_2 $$2MeSH$$aDrosophila melanogaster: metabolism
000269530 650_2 $$2MeSH$$aTubulin: metabolism
000269530 650_2 $$2MeSH$$aDrosophila: metabolism
000269530 650_2 $$2MeSH$$aHumans
000269530 650_2 $$2MeSH$$aNeurons: metabolism
000269530 650_2 $$2MeSH$$aNeurons: cytology
000269530 650_7 $$2Other$$aγ-tubulin
000269530 650_7 $$2Other$$aDrosophila c4da neurons
000269530 650_7 $$2Other$$aAugmin
000269530 650_7 $$2Other$$aHAUS
000269530 650_7 $$2Other$$aHippocampal neurons
000269530 650_7 $$2Other$$aMicrotubules
000269530 650_7 $$2Other$$aNeuronal dendrites
000269530 650_7 $$2Other$$aγ-tubulin
000269530 650_7 $$2NLM Chemicals$$aDrosophila Proteins
000269530 650_7 $$2NLM Chemicals$$aMicrotubule-Associated Proteins
000269530 650_7 $$2NLM Chemicals$$aTubulin
000269530 7001_ $$00009-0006-5175-703X$$aSung, Hsin-Ho$$b1
000269530 7001_ $$0P:(DE-2719)2811714$$aZiegler, Anna$$b2$$udzne
000269530 7001_ $$0P:(DE-HGF)0$$aWu, Ying-Chieh$$b3
000269530 7001_ $$00000-0002-8146-3693$$aViais, Ricardo$$b4
000269530 7001_ $$00000-0002-8797-2093$$aSánchez-Huertas, Carlos$$b5
000269530 7001_ $$0P:(DE-2719)9001797$$aKilo, Lukas$$b6$$udzne
000269530 7001_ $$0P:(DE-2719)2812333$$aAgircan, Fikret Gurkan$$b7
000269530 7001_ $$00009-0007-8211-5854$$aCheng, Ying-Ju$$b8
000269530 7001_ $$00000-0003-1712-6833$$aMouri, Kousuke$$b9
000269530 7001_ $$00000-0001-7204-3606$$aUemura, Tadashi$$b10
000269530 7001_ $$00000-0002-9018-7977$$aLüders, Jens$$b11
000269530 7001_ $$aChien, Cheng-Ting$$b12
000269530 7001_ $$0P:(DE-2719)2810271$$aTavosanis, Gaia$$b13$$eLast author
000269530 773__ $$0PERI:(DE-600)1483099-1$$a10.1242/jcs.261512$$gVol. 137, no. 9, p. jcs261512$$n9$$pjcs261512$$tJournal of cell science$$v137$$x0370-2952$$y2024
000269530 8564_ $$uhttps://pub.dzne.de/record/269530/files/DZNE-2024-00571%2BSUP.pdf$$yOpenAccess
000269530 8564_ $$uhttps://pub.dzne.de/record/269530/files/DZNE-2024-00571%2BSUP.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000269530 909CO $$ooai:pub.dzne.de:269530$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000269530 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000868$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000269530 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811714$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000269530 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001797$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b6$$kDZNE
000269530 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812333$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b7$$kDZNE
000269530 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810271$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b13$$kDZNE
000269530 9131_ $$0G:(DE-HGF)POF4-351$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vBrain Function$$x0
000269530 9141_ $$y2024
000269530 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000269530 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-10-21
000269530 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-10-21
000269530 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-10-21
000269530 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-10-21
000269530 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-10-21
000269530 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ CELL SCI : 2022$$d2023-10-21
000269530 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-10-21
000269530 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-10-21
000269530 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-10-21
000269530 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2023-10-21
000269530 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000269530 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-10-21
000269530 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-10-21
000269530 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2023-10-21
000269530 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-10-21
000269530 9201_ $$0I:(DE-2719)1013018$$kAG Tavosanis$$lDynamics of neuronal circuits$$x0
000269530 980__ $$ajournal
000269530 980__ $$aVDB
000269530 980__ $$aUNRESTRICTED
000269530 980__ $$aI:(DE-2719)1013018
000269530 9801_ $$aFullTexts