% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Zhang:269530,
      author       = {Zhang, Yun and Sung, Hsin-Ho and Ziegler, Anna and Wu,
                      Ying-Chieh and Viais, Ricardo and Sánchez-Huertas, Carlos
                      and Kilo, Lukas and Agircan, Fikret Gurkan and Cheng,
                      Ying-Ju and Mouri, Kousuke and Uemura, Tadashi and Lüders,
                      Jens and Chien, Cheng-Ting and Tavosanis, Gaia},
      title        = {{A}ugmin complex activity finetunes dendrite morphology
                      through non-centrosomal microtubule nucleation in vivo.},
      journal      = {Journal of cell science},
      volume       = {137},
      number       = {9},
      issn         = {0370-2952},
      address      = {Cambridge},
      publisher    = {Company of Biologists Limited},
      reportid     = {DZNE-2024-00571},
      pages        = {jcs261512},
      year         = {2024},
      abstract     = {During development, neurons achieve a stereotyped neuron
                      type-specific morphology, which relies on dynamic support by
                      microtubules (MTs). An important player is the augmin
                      complex (hereafter augmin), which binds to existing MT
                      filaments and recruits the γ-tubulin ring complex
                      (γ-TuRC), to form branched MTs. In cultured neurons, augmin
                      is important for neurite formation. However, little is known
                      about the role of augmin during neurite formation in vivo.
                      Here, we have revisited the role of mammalian augmin in
                      culture and then turned towards the class four Drosophila
                      dendritic arborization (c4da) neurons. We show that MT
                      density is maintained through augmin in cooperation with the
                      γ-TuRC in vivo. Mutant c4da neurons show a reduction of
                      newly emerging higher-order dendritic branches and in turn
                      also a reduced number of their characteristic space-filling
                      higher-order branchlets. Taken together, our data reveal a
                      cooperative function for augmin with the γ-TuRC in forming
                      enough MTs needed for the appropriate differentiation of
                      morphologically complex dendrites in vivo.},
      keywords     = {Animals / Microtubules: metabolism / Dendrites: metabolism
                      / Drosophila Proteins: metabolism / Drosophila Proteins:
                      genetics / Microtubule-Associated Proteins: metabolism /
                      Microtubule-Associated Proteins: genetics / Drosophila
                      melanogaster: metabolism / Tubulin: metabolism / Drosophila:
                      metabolism / Humans / Neurons: metabolism / Neurons:
                      cytology / γ-tubulin (Other) / Drosophila c4da neurons
                      (Other) / Augmin (Other) / HAUS (Other) / Hippocampal
                      neurons (Other) / Microtubules (Other) / Neuronal dendrites
                      (Other) / γ-tubulin (Other) / Drosophila Proteins (NLM
                      Chemicals) / Microtubule-Associated Proteins (NLM Chemicals)
                      / Tubulin (NLM Chemicals)},
      cin          = {AG Tavosanis},
      ddc          = {570},
      cid          = {I:(DE-2719)1013018},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC11128282},
      pubmed       = {pmid:38587100},
      doi          = {10.1242/jcs.261512},
      url          = {https://pub.dzne.de/record/269530},
}