%0 Journal Article
%A Bollack, Ariane
%A Collij, Lyduine E
%A García, David Vállez
%A Shekari, Mahnaz
%A Altomare, Daniele
%A Payoux, Pierre
%A Dubois, Bruno
%A Grau-Rivera, Oriol
%A Boada, Mercè
%A Marquié, Marta
%A Nordberg, Agneta
%A Walker, Zuzana
%A Scheltens, Philip
%A Schöll, Michael
%A Wolz, Robin
%A Schott, Jonathan M
%A Gismondi, Rossella
%A Stephens, Andrew
%A Buckley, Christopher
%A Frisoni, Giovanni B
%A Hanseeuw, Bernard
%A Visser, Pieter Jelle
%A Vandenberghe, Rik
%A Drzezga, Alexander
%A Yaqub, Maqsood
%A Boellaard, Ronald
%A Gispert, Juan Domingo
%A Markiewicz, Pawel
%A Cash, David M
%A Farrar, Gill
%A Barkhof, Frederik
%T Investigating reliable amyloid accumulation in Centiloids: Results from the AMYPAD Prognostic and Natural History Study.
%J Alzheimer's and dementia
%V 20
%N 5
%@ 1552-5260
%C Hoboken, NJ
%I Wiley
%M DZNE-2024-00595
%P 3429 - 3441
%D 2024
%X To support clinical trial designs focused on early interventions, our study determined reliable early amyloid-β (Aβ) accumulation based on Centiloids (CL) in pre-dementia populations.A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease-Prognostic and Natural History Study (AMYPAD-PNHS) and Insight46 who underwent [18F]flutemetamol, [18F]florbetaben or [18F]florbetapir amyloid-PET were included. A normative strategy was used to define reliable accumulation by estimating the 95th percentile of longitudinal measurements in sub-populations (NPNHS = 101/750, NInsight46 = 35/382) expected to remain stable over time. The baseline CL threshold that optimally predicts future accumulation was investigated using precision-recall analyses. Accumulation rates were examined using linear mixed-effect models.Reliable accumulation in the PNHS was estimated to occur at >3.0 CL/year. Baseline CL of 16 [12,19] best predicted future Aβ-accumulators. Rates of amyloid accumulation were tracer-independent, lower for APOE ε4 non-carriers, and for subjects with higher levels of education.Our results support a 12-20 CL window for inclusion into early secondary prevention studies. Reliable accumulation definition warrants further investigations.
%K Humans
%K Male
%K Female
%K Positron-Emission Tomography
%K Aged
%K Amyloid beta-Peptides: metabolism
%K Alzheimer Disease: diagnostic imaging
%K Alzheimer Disease: metabolism
%K Aniline Compounds
%K Prognosis
%K Middle Aged
%K Longitudinal Studies
%K Stilbenes
%K Brain: diagnostic imaging
%K Brain: metabolism
%K Benzothiazoles
%K Alzheimer's (Other)
%K Centiloid (Other)
%K amyloid (Other)
%K longitudinal PET (Other)
%K quantification (Other)
%K reliable accumulation (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38574374
%2 pmc:PMC11095430
%R 10.1002/alz.13761
%U https://pub.dzne.de/record/269681