TY  - JOUR
AU  - Bollack, Ariane
AU  - Collij, Lyduine E
AU  - García, David Vállez
AU  - Shekari, Mahnaz
AU  - Altomare, Daniele
AU  - Payoux, Pierre
AU  - Dubois, Bruno
AU  - Grau-Rivera, Oriol
AU  - Boada, Mercè
AU  - Marquié, Marta
AU  - Nordberg, Agneta
AU  - Walker, Zuzana
AU  - Scheltens, Philip
AU  - Schöll, Michael
AU  - Wolz, Robin
AU  - Schott, Jonathan M
AU  - Gismondi, Rossella
AU  - Stephens, Andrew
AU  - Buckley, Christopher
AU  - Frisoni, Giovanni B
AU  - Hanseeuw, Bernard
AU  - Visser, Pieter Jelle
AU  - Vandenberghe, Rik
AU  - Drzezga, Alexander
AU  - Yaqub, Maqsood
AU  - Boellaard, Ronald
AU  - Gispert, Juan Domingo
AU  - Markiewicz, Pawel
AU  - Cash, David M
AU  - Farrar, Gill
AU  - Barkhof, Frederik
TI  - Investigating reliable amyloid accumulation in Centiloids: Results from the AMYPAD Prognostic and Natural History Study.
JO  - Alzheimer's and dementia
VL  - 20
IS  - 5
SN  - 1552-5260
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2024-00595
SP  - 3429 - 3441
PY  - 2024
AB  - To support clinical trial designs focused on early interventions, our study determined reliable early amyloid-β (Aβ) accumulation based on Centiloids (CL) in pre-dementia populations.A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease-Prognostic and Natural History Study (AMYPAD-PNHS) and Insight46 who underwent [18F]flutemetamol, [18F]florbetaben or [18F]florbetapir amyloid-PET were included. A normative strategy was used to define reliable accumulation by estimating the 95th percentile of longitudinal measurements in sub-populations (NPNHS = 101/750, NInsight46 = 35/382) expected to remain stable over time. The baseline CL threshold that optimally predicts future accumulation was investigated using precision-recall analyses. Accumulation rates were examined using linear mixed-effect models.Reliable accumulation in the PNHS was estimated to occur at >3.0 CL/year. Baseline CL of 16 [12,19] best predicted future Aβ-accumulators. Rates of amyloid accumulation were tracer-independent, lower for APOE ε4 non-carriers, and for subjects with higher levels of education.Our results support a 12-20 CL window for inclusion into early secondary prevention studies. Reliable accumulation definition warrants further investigations.
KW  - Humans
KW  - Male
KW  - Female
KW  - Positron-Emission Tomography
KW  - Aged
KW  - Amyloid beta-Peptides: metabolism
KW  - Alzheimer Disease: diagnostic imaging
KW  - Alzheimer Disease: metabolism
KW  - Aniline Compounds
KW  - Prognosis
KW  - Middle Aged
KW  - Longitudinal Studies
KW  - Stilbenes
KW  - Brain: diagnostic imaging
KW  - Brain: metabolism
KW  - Benzothiazoles
KW  - Alzheimer's (Other)
KW  - Centiloid (Other)
KW  - amyloid (Other)
KW  - longitudinal PET (Other)
KW  - quantification (Other)
KW  - reliable accumulation (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38574374
C2  - pmc:PMC11095430
DO  - DOI:10.1002/alz.13761
UR  - https://pub.dzne.de/record/269681
ER  -