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@ARTICLE{Bollack:269681,
      author       = {Bollack, Ariane and Collij, Lyduine E and García, David
                      Vállez and Shekari, Mahnaz and Altomare, Daniele and
                      Payoux, Pierre and Dubois, Bruno and Grau-Rivera, Oriol and
                      Boada, Mercè and Marquié, Marta and Nordberg, Agneta and
                      Walker, Zuzana and Scheltens, Philip and Schöll, Michael
                      and Wolz, Robin and Schott, Jonathan M and Gismondi,
                      Rossella and Stephens, Andrew and Buckley, Christopher and
                      Frisoni, Giovanni B and Hanseeuw, Bernard and Visser, Pieter
                      Jelle and Vandenberghe, Rik and Drzezga, Alexander and
                      Yaqub, Maqsood and Boellaard, Ronald and Gispert, Juan
                      Domingo and Markiewicz, Pawel and Cash, David M and Farrar,
                      Gill and Barkhof, Frederik},
      collaboration = {consortium, AMYPAD},
      title        = {{I}nvestigating reliable amyloid accumulation in
                      {C}entiloids: {R}esults from the {AMYPAD} {P}rognostic and
                      {N}atural {H}istory {S}tudy.},
      journal      = {Alzheimer's and dementia},
      volume       = {20},
      number       = {5},
      issn         = {1552-5260},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2024-00595},
      pages        = {3429 - 3441},
      year         = {2024},
      abstract     = {To support clinical trial designs focused on early
                      interventions, our study determined reliable early
                      amyloid-β (Aβ) accumulation based on Centiloids (CL) in
                      pre-dementia populations.A total of 1032 participants from
                      the Amyloid Imaging to Prevent Alzheimer's
                      Disease-Prognostic and Natural History Study (AMYPAD-PNHS)
                      and Insight46 who underwent [18F]flutemetamol,
                      [18F]florbetaben or [18F]florbetapir amyloid-PET were
                      included. A normative strategy was used to define reliable
                      accumulation by estimating the 95th percentile of
                      longitudinal measurements in sub-populations (NPNHS =
                      101/750, NInsight46 = 35/382) expected to remain stable over
                      time. The baseline CL threshold that optimally predicts
                      future accumulation was investigated using precision-recall
                      analyses. Accumulation rates were examined using linear
                      mixed-effect models.Reliable accumulation in the PNHS was
                      estimated to occur at >3.0 CL/year. Baseline CL of 16
                      [12,19] best predicted future Aβ-accumulators. Rates of
                      amyloid accumulation were tracer-independent, lower for APOE
                      ε4 non-carriers, and for subjects with higher levels of
                      education.Our results support a 12-20 CL window for
                      inclusion into early secondary prevention studies. Reliable
                      accumulation definition warrants further investigations.},
      keywords     = {Humans / Male / Female / Positron-Emission Tomography /
                      Aged / Amyloid beta-Peptides: metabolism / Alzheimer
                      Disease: diagnostic imaging / Alzheimer Disease: metabolism
                      / Aniline Compounds / Prognosis / Middle Aged / Longitudinal
                      Studies / Stilbenes / Brain: diagnostic imaging / Brain:
                      metabolism / Benzothiazoles / Alzheimer's (Other) /
                      Centiloid (Other) / amyloid (Other) / longitudinal PET
                      (Other) / quantification (Other) / reliable accumulation
                      (Other)},
      cin          = {AG Boecker},
      ddc          = {610},
      cid          = {I:(DE-2719)1011202},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38574374},
      pmc          = {pmc:PMC11095430},
      doi          = {10.1002/alz.13761},
      url          = {https://pub.dzne.de/record/269681},
}