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| 001 | 269681 | ||
| 005 | 20240526004109.0 | ||
| 024 | 7 | _ | |a 10.1002/alz.13761 |2 doi |
| 024 | 7 | _ | |a pmid:38574374 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC11095430 |2 pmc |
| 024 | 7 | _ | |a 1552-5260 |2 ISSN |
| 024 | 7 | _ | |a 1552-5279 |2 ISSN |
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| 037 | _ | _ | |a DZNE-2024-00595 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Bollack, Ariane |0 0000-0002-9169-7530 |b 0 |
| 245 | _ | _ | |a Investigating reliable amyloid accumulation in Centiloids: Results from the AMYPAD Prognostic and Natural History Study. |
| 260 | _ | _ | |a Hoboken, NJ |c 2024 |b Wiley |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1716453713_3149 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a To support clinical trial designs focused on early interventions, our study determined reliable early amyloid-β (Aβ) accumulation based on Centiloids (CL) in pre-dementia populations.A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease-Prognostic and Natural History Study (AMYPAD-PNHS) and Insight46 who underwent [18F]flutemetamol, [18F]florbetaben or [18F]florbetapir amyloid-PET were included. A normative strategy was used to define reliable accumulation by estimating the 95th percentile of longitudinal measurements in sub-populations (NPNHS = 101/750, NInsight46 = 35/382) expected to remain stable over time. The baseline CL threshold that optimally predicts future accumulation was investigated using precision-recall analyses. Accumulation rates were examined using linear mixed-effect models.Reliable accumulation in the PNHS was estimated to occur at >3.0 CL/year. Baseline CL of 16 [12,19] best predicted future Aβ-accumulators. Rates of amyloid accumulation were tracer-independent, lower for APOE ε4 non-carriers, and for subjects with higher levels of education.Our results support a 12-20 CL window for inclusion into early secondary prevention studies. Reliable accumulation definition warrants further investigations. |
| 536 | _ | _ | |a 353 - Clinical and Health Care Research (POF4-353) |0 G:(DE-HGF)POF4-353 |c POF4-353 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a Alzheimer's |2 Other |
| 650 | _ | 7 | |a Centiloid |2 Other |
| 650 | _ | 7 | |a amyloid |2 Other |
| 650 | _ | 7 | |a longitudinal PET |2 Other |
| 650 | _ | 7 | |a quantification |2 Other |
| 650 | _ | 7 | |a reliable accumulation |2 Other |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Positron-Emission Tomography |2 MeSH |
| 650 | _ | 2 | |a Aged |2 MeSH |
| 650 | _ | 2 | |a Amyloid beta-Peptides: metabolism |2 MeSH |
| 650 | _ | 2 | |a Alzheimer Disease: diagnostic imaging |2 MeSH |
| 650 | _ | 2 | |a Alzheimer Disease: metabolism |2 MeSH |
| 650 | _ | 2 | |a Aniline Compounds |2 MeSH |
| 650 | _ | 2 | |a Prognosis |2 MeSH |
| 650 | _ | 2 | |a Middle Aged |2 MeSH |
| 650 | _ | 2 | |a Longitudinal Studies |2 MeSH |
| 650 | _ | 2 | |a Stilbenes |2 MeSH |
| 650 | _ | 2 | |a Brain: diagnostic imaging |2 MeSH |
| 650 | _ | 2 | |a Brain: metabolism |2 MeSH |
| 650 | _ | 2 | |a Benzothiazoles |2 MeSH |
| 700 | 1 | _ | |a Collij, Lyduine E |0 0000-0001-6263-1762 |b 1 |
| 700 | 1 | _ | |a García, David Vállez |0 0000-0003-3308-3167 |b 2 |
| 700 | 1 | _ | |a Shekari, Mahnaz |0 0000-0003-1336-6768 |b 3 |
| 700 | 1 | _ | |a Altomare, Daniele |0 0000-0003-1905-8993 |b 4 |
| 700 | 1 | _ | |a Payoux, Pierre |b 5 |
| 700 | 1 | _ | |a Dubois, Bruno |b 6 |
| 700 | 1 | _ | |a Grau-Rivera, Oriol |b 7 |
| 700 | 1 | _ | |a Boada, Mercè |0 0000-0003-2617-3009 |b 8 |
| 700 | 1 | _ | |a Marquié, Marta |0 0000-0002-0660-0950 |b 9 |
| 700 | 1 | _ | |a Nordberg, Agneta |b 10 |
| 700 | 1 | _ | |a Walker, Zuzana |0 0000-0001-7346-8200 |b 11 |
| 700 | 1 | _ | |a Scheltens, Philip |b 12 |
| 700 | 1 | _ | |a Schöll, Michael |b 13 |
| 700 | 1 | _ | |a Wolz, Robin |b 14 |
| 700 | 1 | _ | |a Schott, Jonathan M |b 15 |
| 700 | 1 | _ | |a Gismondi, Rossella |b 16 |
| 700 | 1 | _ | |a Stephens, Andrew |0 0000-0001-5052-6586 |b 17 |
| 700 | 1 | _ | |a Buckley, Christopher |b 18 |
| 700 | 1 | _ | |a Frisoni, Giovanni B |b 19 |
| 700 | 1 | _ | |a Hanseeuw, Bernard |0 0000-0002-3102-6778 |b 20 |
| 700 | 1 | _ | |a Visser, Pieter Jelle |b 21 |
| 700 | 1 | _ | |a Vandenberghe, Rik |b 22 |
| 700 | 1 | _ | |a Drzezga, Alexander |0 P:(DE-2719)2811239 |b 23 |u dzne |
| 700 | 1 | _ | |a Yaqub, Maqsood |b 24 |
| 700 | 1 | _ | |a Boellaard, Ronald |b 25 |
| 700 | 1 | _ | |a Gispert, Juan Domingo |0 0000-0002-6155-0642 |b 26 |
| 700 | 1 | _ | |a Markiewicz, Pawel |0 0000-0002-3114-0773 |b 27 |
| 700 | 1 | _ | |a Cash, David M |0 0000-0001-7833-616X |b 28 |
| 700 | 1 | _ | |a Farrar, Gill |b 29 |
| 700 | 1 | _ | |a Barkhof, Frederik |0 0000-0003-3543-3706 |b 30 |
| 700 | 1 | _ | |a consortium, AMYPAD |b 31 |e Collaboration Author |
| 773 | _ | _ | |a 10.1002/alz.13761 |g Vol. 20, no. 5, p. 3429 - 3441 |0 PERI:(DE-600)2201940-6 |n 5 |p 3429 - 3441 |t Alzheimer's and dementia |v 20 |y 2024 |x 1552-5260 |
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