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000269686 1001_ $$aPapazoglou, Anna$$b0
000269686 245__ $$aSex-specific cortical, hippocampal and thalamic whole genome transcriptome data from controls and a G72 schizophrenia mouse model.
000269686 260__ $$aLondon$$b[Verlag nicht ermittelbar]$$c2024
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000269686 520__ $$aThe G72 mouse model of schizophrenia represents a well-known model that was generated to meet the main translational criteria of isomorphism, homology and predictability of schizophrenia to a maximum extent. In order to get a more detailed view of the complex etiopathogenesis of schizophrenia, whole genome transcriptome studies turn out to be indispensable. Here we carried out microarray data collection based on RNA extracted from the retrosplenial cortex, hippocampus and thalamus of G72 transgenic and wild-type control mice. Experimental animals were age-matched and importantly, both sexes were considered separately.The isolated RNA from all three brain regions was purified, quantified und quality controlled before initiation of the hybridization procedure with SurePrint G3 Mouse Gene Expression v2 8 × 60 K microarrays. Following immunofluorescent measurement und preprocessing of image data, raw transcriptome data from G72 mice and control animals were extracted and uploaded in a public database. Our data allow insight into significant alterations in gene transcript levels in G72 mice and enable the reader/user to perform further complex analyses to identify potential age-, sex- and brain-region-specific alterations in transcription profiles and related pathways. The latter could facilitate biomarker identification and drug research and development in schizophrenia research.
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000269686 650_7 $$2Other$$aBrain
000269686 650_7 $$2Other$$aFold change
000269686 650_7 $$2Other$$aHippocampus
000269686 650_7 $$2Other$$aHybridization
000269686 650_7 $$2Other$$aMicroarray
000269686 650_7 $$2Other$$aRNA
000269686 650_7 $$2Other$$aRetrosplenial cortex
000269686 650_7 $$2Other$$aSchizophrenia
000269686 650_7 $$2Other$$aThalamus
000269686 650_7 $$2Other$$aTranscriptome
000269686 650_2 $$2MeSH$$aAnimals
000269686 650_2 $$2MeSH$$aSchizophrenia: genetics
000269686 650_2 $$2MeSH$$aSchizophrenia: metabolism
000269686 650_2 $$2MeSH$$aHippocampus: metabolism
000269686 650_2 $$2MeSH$$aMale
000269686 650_2 $$2MeSH$$aFemale
000269686 650_2 $$2MeSH$$aMice
000269686 650_2 $$2MeSH$$aDisease Models, Animal
000269686 650_2 $$2MeSH$$aTranscriptome: genetics
000269686 650_2 $$2MeSH$$aCerebral Cortex: metabolism
000269686 650_2 $$2MeSH$$aCerebral Cortex: pathology
000269686 650_2 $$2MeSH$$aThalamus: metabolism
000269686 650_2 $$2MeSH$$aMice, Transgenic
000269686 650_2 $$2MeSH$$aGene Expression Profiling: methods
000269686 650_2 $$2MeSH$$aSex Factors
000269686 7001_ $$aHenseler, Christina$$b1
000269686 7001_ $$aWeickhardt, Sandra$$b2
000269686 7001_ $$aDaubner, Johanna$$b3
000269686 7001_ $$aSchiffer, Teresa$$b4
000269686 7001_ $$aBroich, Karl$$b5
000269686 7001_ $$aHescheler, Jürgen$$b6
000269686 7001_ $$aSachinidis, Agapios$$b7
000269686 7001_ $$0P:(DE-2719)2289209$$aEhninger, Dan$$b8$$udzne
000269686 7001_ $$0P:(DE-2719)2810511$$aHaenisch, Britta$$b9$$udzne
000269686 7001_ $$aWeiergräber, Marco$$b10
000269686 773__ $$0PERI:(DE-600)2413336-X$$a10.1186/s13104-024-06799-4$$gVol. 17, no. 1, p. 143$$n1$$p143$$tBMC Research Notes$$v17$$x1756-0500$$y2024
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