TY  - JOUR
AU  - Papazoglou, Anna
AU  - Henseler, Christina
AU  - Weickhardt, Sandra
AU  - Daubner, Johanna
AU  - Schiffer, Teresa
AU  - Broich, Karl
AU  - Hescheler, Jürgen
AU  - Sachinidis, Agapios
AU  - Ehninger, Dan
AU  - Haenisch, Britta
AU  - Weiergräber, Marco
TI  - Sex-specific cortical, hippocampal and thalamic whole genome transcriptome data from controls and a G72 schizophrenia mouse model.
JO  - BMC Research Notes
VL  - 17
IS  - 1
SN  - 1756-0500
CY  - London
PB  - [Verlag nicht ermittelbar]
M1  - DZNE-2024-00600
SP  - 143
PY  - 2024
AB  - The G72 mouse model of schizophrenia represents a well-known model that was generated to meet the main translational criteria of isomorphism, homology and predictability of schizophrenia to a maximum extent. In order to get a more detailed view of the complex etiopathogenesis of schizophrenia, whole genome transcriptome studies turn out to be indispensable. Here we carried out microarray data collection based on RNA extracted from the retrosplenial cortex, hippocampus and thalamus of G72 transgenic and wild-type control mice. Experimental animals were age-matched and importantly, both sexes were considered separately.The isolated RNA from all three brain regions was purified, quantified und quality controlled before initiation of the hybridization procedure with SurePrint G3 Mouse Gene Expression v2 8 × 60 K microarrays. Following immunofluorescent measurement und preprocessing of image data, raw transcriptome data from G72 mice and control animals were extracted and uploaded in a public database. Our data allow insight into significant alterations in gene transcript levels in G72 mice and enable the reader/user to perform further complex analyses to identify potential age-, sex- and brain-region-specific alterations in transcription profiles and related pathways. The latter could facilitate biomarker identification and drug research and development in schizophrenia research.
KW  - Animals
KW  - Schizophrenia: genetics
KW  - Schizophrenia: metabolism
KW  - Hippocampus: metabolism
KW  - Male
KW  - Female
KW  - Mice
KW  - Disease Models, Animal
KW  - Transcriptome: genetics
KW  - Cerebral Cortex: metabolism
KW  - Cerebral Cortex: pathology
KW  - Thalamus: metabolism
KW  - Mice, Transgenic
KW  - Gene Expression Profiling: methods
KW  - Sex Factors
KW  - Brain (Other)
KW  - Fold change (Other)
KW  - Hippocampus (Other)
KW  - Hybridization (Other)
KW  - Microarray (Other)
KW  - RNA (Other)
KW  - Retrosplenial cortex (Other)
KW  - Schizophrenia (Other)
KW  - Thalamus (Other)
KW  - Transcriptome (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC11110308
C6  - pmid:38773625
DO  - DOI:10.1186/s13104-024-06799-4
UR  - https://pub.dzne.de/record/269686
ER  -