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000269775 1001_ $$00000-0002-0257-3027$$aGiusti, Sebastian A$$b0
000269775 245__ $$aA brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli.
000269775 260__ $$aWashington, DC [u.a.]$$bAssoc.$$c2024
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000269775 520__ $$aCircular RNAs (circRNAs) are a large class of noncoding RNAs. Despite the identification of thousands of circular transcripts, the biological significance of most of them remains unexplored, partly because of the lack of effective methods for generating loss-of-function animal models. In this study, we focused on circTulp4, an abundant circRNA derived from the Tulp4 gene that is enriched in the brain and synaptic compartments. By creating a circTulp4-deficient mouse model, in which we mutated the splice acceptor site responsible for generating circTulp4 without affecting the linear mRNA or protein levels, we were able to conduct a comprehensive phenotypic analysis. Our results demonstrate that circTulp4 is critical in regulating neuronal and brain physiology, modulating the strength of excitatory neurotransmission and sensitivity to aversive stimuli. This study provides evidence that circRNAs can regulate biologically relevant functions in neurons, with modulatory effects at multiple levels of the phenotype, establishing a proof of principle for the regulatory role of circRNAs in neural processes.
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000269775 650_7 $$2NLM Chemicals$$aRNA, Circular
000269775 650_2 $$2MeSH$$aRNA, Circular: genetics
000269775 650_2 $$2MeSH$$aAnimals
000269775 650_2 $$2MeSH$$aSynaptic Transmission
000269775 650_2 $$2MeSH$$aMice
000269775 650_2 $$2MeSH$$aBrain: metabolism
000269775 650_2 $$2MeSH$$aBrain: physiology
000269775 650_2 $$2MeSH$$aMice, Knockout
000269775 650_2 $$2MeSH$$aNeurons: metabolism
000269775 650_2 $$2MeSH$$aNeurons: physiology
000269775 7001_ $$00009-0001-6984-1751$$aPino, Natalia S$$b1
000269775 7001_ $$aPannunzio, Camila$$b2
000269775 7001_ $$00000-0002-1453-2628$$aOgando, Mora B$$b3
000269775 7001_ $$00000-0003-1379-4025$$aArmando, Natalia G$$b4
000269775 7001_ $$00000-0003-4880-7076$$aGarrett, Lillian$$b5
000269775 7001_ $$00000-0003-2078-6779$$aZimprich, Annemarie$$b6
000269775 7001_ $$00000-0002-6890-4984$$aBecker, Lore$$b7
000269775 7001_ $$aGimeno, Maria L$$b8
000269775 7001_ $$00000-0002-2284-7152$$aLukin, Jeronimo$$b9
000269775 7001_ $$00000-0001-7247-2750$$aMerino, Florencia L$$b10
000269775 7001_ $$00000-0003-1942-7533$$aPardi, M Belen$$b11
000269775 7001_ $$00009-0009-0613-4126$$aPedroncini, Olivia$$b12
000269775 7001_ $$00000-0001-5685-090X$$aDi Mauro, Giuliana C$$b13
000269775 7001_ $$aDurner, Valerie Gailus$$b14
000269775 7001_ $$aFuchs, Helmut$$b15
000269775 7001_ $$0P:(DE-2719)9000920$$ade Angelis, Martin Hrabě$$b16
000269775 7001_ $$00000-0002-2929-0860$$aPatop, Ines L$$b17
000269775 7001_ $$00000-0002-6585-8636$$aTurck, Christoph W$$b18
000269775 7001_ $$00000-0002-9329-5252$$aDeussing, Jan M$$b19
000269775 7001_ $$00000-0002-4566-6506$$aVogt Weisenhorn, Daniela M$$b20
000269775 7001_ $$00000-0002-3397-8924$$aJahn, Olaf$$b21
000269775 7001_ $$aKadener, Sebastian$$b22
000269775 7001_ $$00000-0003-4878-5241$$aHölter, Sabine M$$b23
000269775 7001_ $$00000-0003-0938-8534$$aBrose, Nils$$b24
000269775 7001_ $$0P:(DE-2719)9001454$$aGiesert, Florian$$b25
000269775 7001_ $$0P:(DE-2719)2000028$$aWurst, Wolfgang$$b26
000269775 7001_ $$00000-0003-0684-9796$$aMarin-Burgin, Antonia$$b27
000269775 7001_ $$00000-0002-9798-6413$$aRefojo, Damian$$b28
000269775 773__ $$0PERI:(DE-600)2810933-8$$a10.1126/sciadv.adj8769$$gVol. 10, no. 21, p. eadj8769$$n21$$peadj8769$$tScience advances$$v10$$x2375-2548$$y2024
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