% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Giusti:269775,
      author       = {Giusti, Sebastian A and Pino, Natalia S and Pannunzio,
                      Camila and Ogando, Mora B and Armando, Natalia G and
                      Garrett, Lillian and Zimprich, Annemarie and Becker, Lore
                      and Gimeno, Maria L and Lukin, Jeronimo and Merino,
                      Florencia L and Pardi, M Belen and Pedroncini, Olivia and Di
                      Mauro, Giuliana C and Durner, Valerie Gailus and Fuchs,
                      Helmut and de Angelis, Martin Hrabě and Patop, Ines L and
                      Turck, Christoph W and Deussing, Jan M and Vogt Weisenhorn,
                      Daniela M and Jahn, Olaf and Kadener, Sebastian and Hölter,
                      Sabine M and Brose, Nils and Giesert, Florian and Wurst,
                      Wolfgang and Marin-Burgin, Antonia and Refojo, Damian},
      title        = {{A} brain-enriched circular {RNA} controls excitatory
                      neurotransmission and restricts sensitivity to aversive
                      stimuli.},
      journal      = {Science advances},
      volume       = {10},
      number       = {21},
      issn         = {2375-2548},
      address      = {Washington, DC [u.a.]},
      publisher    = {Assoc.},
      reportid     = {DZNE-2024-00617},
      pages        = {eadj8769},
      year         = {2024},
      abstract     = {Circular RNAs (circRNAs) are a large class of noncoding
                      RNAs. Despite the identification of thousands of circular
                      transcripts, the biological significance of most of them
                      remains unexplored, partly because of the lack of effective
                      methods for generating loss-of-function animal models. In
                      this study, we focused on circTulp4, an abundant circRNA
                      derived from the Tulp4 gene that is enriched in the brain
                      and synaptic compartments. By creating a circTulp4-deficient
                      mouse model, in which we mutated the splice acceptor site
                      responsible for generating circTulp4 without affecting the
                      linear mRNA or protein levels, we were able to conduct a
                      comprehensive phenotypic analysis. Our results demonstrate
                      that circTulp4 is critical in regulating neuronal and brain
                      physiology, modulating the strength of excitatory
                      neurotransmission and sensitivity to aversive stimuli. This
                      study provides evidence that circRNAs can regulate
                      biologically relevant functions in neurons, with modulatory
                      effects at multiple levels of the phenotype, establishing a
                      proof of principle for the regulatory role of circRNAs in
                      neural processes.},
      keywords     = {RNA, Circular: genetics / Animals / Synaptic Transmission /
                      Mice / Brain: metabolism / Brain: physiology / Mice,
                      Knockout / Neurons: metabolism / Neurons: physiology / RNA,
                      Circular (NLM Chemicals)},
      cin          = {AG Wurst},
      ddc          = {500},
      cid          = {I:(DE-2719)1140001},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38787942},
      pmc          = {pmc:PMC11122670},
      doi          = {10.1126/sciadv.adj8769},
      url          = {https://pub.dzne.de/record/269775},
}