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000269784 1001_ $$00000-0002-7957-8643$$avan Veluw, Susanne J$$b0
000269784 245__ $$aIs CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies.
000269784 260__ $$aCham (ZG)$$bSpringer International Publishing AG$$c2024
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000269784 520__ $$aThe brain's network of perivascular channels for clearance of excess fluids and waste plays a critical role in the pathogenesis of several neurodegenerative diseases including cerebral amyloid angiopathy (CAA). CAA is the main cause of hemorrhagic stroke in the elderly, the most common vascular comorbidity in Alzheimer's disease and also implicated in adverse events related to anti-amyloid immunotherapy. Remarkably, the mechanisms governing perivascular clearance of soluble amyloid β-a key culprit in CAA-from the brain to draining lymphatics and systemic circulation remains poorly understood. This knowledge gap is critically important to bridge for understanding the pathophysiology of CAA and accelerate development of targeted therapeutics. The authors of this review recently converged their diverse expertise in the field of perivascular physiology to specifically address this problem within the framework of a Leducq Foundation Transatlantic Network of Excellence on Brain Clearance. This review discusses the overarching goal of the consortium and explores the evidence supporting or refuting the role of impaired perivascular clearance in the pathophysiology of CAA with a focus on translating observations from rodents to humans. We also discuss the anatomical features of perivascular channels as well as the biophysical characteristics of fluid and solute transport.
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000269784 650_7 $$2Other$$aBrain clearance
000269784 650_7 $$2Other$$aCerebral amyloid angiopathy
000269784 650_7 $$2Other$$aCerebrospinal fluid
000269784 650_7 $$2Other$$aGlymphatics
000269784 650_7 $$2Other$$aIPAD
000269784 650_7 $$2Other$$aPerivascular spaces
000269784 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000269784 650_2 $$2MeSH$$aHumans
000269784 650_2 $$2MeSH$$aBrain: metabolism
000269784 650_2 $$2MeSH$$aBrain: pathology
000269784 650_2 $$2MeSH$$aCerebral Amyloid Angiopathy: metabolism
000269784 650_2 $$2MeSH$$aCerebral Amyloid Angiopathy: pathology
000269784 650_2 $$2MeSH$$aAnimals
000269784 650_2 $$2MeSH$$aAmyloid beta-Peptides: metabolism
000269784 650_2 $$2MeSH$$aGlymphatic System: metabolism
000269784 650_2 $$2MeSH$$aGlymphatic System: pathology
000269784 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000269784 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000269784 7001_ $$aBenveniste, Helene$$b1
000269784 7001_ $$aBakker, Erik N T P$$b2
000269784 7001_ $$aCarare, Roxana O$$b3
000269784 7001_ $$aGreenberg, Steven M$$b4
000269784 7001_ $$aIliff, Jeffrey J$$b5
000269784 7001_ $$aLorthois, Sylvie$$b6
000269784 7001_ $$aVan Nostrand, William E$$b7
000269784 7001_ $$0P:(DE-2719)2810273$$aPetzold, Gabor C$$b8$$udzne
000269784 7001_ $$aShih, Andy Y$$b9
000269784 7001_ $$avan Osch, Matthias J P$$b10
000269784 773__ $$0PERI:(DE-600)1458497-9$$a10.1007/s00018-024-05277-1$$gVol. 81, no. 1, p. 239$$n1$$p239$$tCellular and molecular life sciences$$v81$$x1420-682X$$y2024
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