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@ARTICLE{vanVeluw:269784,
      author       = {van Veluw, Susanne J and Benveniste, Helene and Bakker,
                      Erik N T P and Carare, Roxana O and Greenberg, Steven M and
                      Iliff, Jeffrey J and Lorthois, Sylvie and Van Nostrand,
                      William E and Petzold, Gabor C and Shih, Andy Y and van
                      Osch, Matthias J P},
      title        = {{I}s {CAA} a perivascular brain clearance disease? {A}
                      discussion of the evidence to date and outlook for future
                      studies.},
      journal      = {Cellular and molecular life sciences},
      volume       = {81},
      number       = {1},
      issn         = {1420-682X},
      address      = {Cham (ZG)},
      publisher    = {Springer International Publishing AG},
      reportid     = {DZNE-2024-00619},
      pages        = {239},
      year         = {2024},
      abstract     = {The brain's network of perivascular channels for clearance
                      of excess fluids and waste plays a critical role in the
                      pathogenesis of several neurodegenerative diseases including
                      cerebral amyloid angiopathy (CAA). CAA is the main cause of
                      hemorrhagic stroke in the elderly, the most common vascular
                      comorbidity in Alzheimer's disease and also implicated in
                      adverse events related to anti-amyloid immunotherapy.
                      Remarkably, the mechanisms governing perivascular clearance
                      of soluble amyloid β-a key culprit in CAA-from the brain to
                      draining lymphatics and systemic circulation remains poorly
                      understood. This knowledge gap is critically important to
                      bridge for understanding the pathophysiology of CAA and
                      accelerate development of targeted therapeutics. The authors
                      of this review recently converged their diverse expertise in
                      the field of perivascular physiology to specifically address
                      this problem within the framework of a Leducq Foundation
                      Transatlantic Network of Excellence on Brain Clearance. This
                      review discusses the overarching goal of the consortium and
                      explores the evidence supporting or refuting the role of
                      impaired perivascular clearance in the pathophysiology of
                      CAA with a focus on translating observations from rodents to
                      humans. We also discuss the anatomical features of
                      perivascular channels as well as the biophysical
                      characteristics of fluid and solute transport.},
      subtyp        = {Review Article},
      keywords     = {Humans / Brain: metabolism / Brain: pathology / Cerebral
                      Amyloid Angiopathy: metabolism / Cerebral Amyloid
                      Angiopathy: pathology / Animals / Amyloid beta-Peptides:
                      metabolism / Glymphatic System: metabolism / Glymphatic
                      System: pathology / Alzheimer Disease: metabolism /
                      Alzheimer Disease: pathology / Brain clearance (Other) /
                      Cerebral amyloid angiopathy (Other) / Cerebrospinal fluid
                      (Other) / Glymphatics (Other) / IPAD (Other) / Perivascular
                      spaces (Other) / Amyloid beta-Peptides (NLM Chemicals)},
      cin          = {AG Petzold ; AG Petzold},
      ddc          = {610},
      cid          = {I:(DE-2719)1013020},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC11130115},
      pubmed       = {pmid:38801464},
      doi          = {10.1007/s00018-024-05277-1},
      url          = {https://pub.dzne.de/record/269784},
}