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@ARTICLE{Aziz:270185,
      author       = {Aziz, N. Ahmad and Santos, Marina and Breteler, Monique},
      title        = {{T}he association between {SARS}-{C}o{V}-2 infection and
                      neuronal damage: {A} population-based nested case-control
                      study},
      reportid     = {DZNE-2024-00756},
      year         = {2021},
      abstract     = {Objective: To assess whether severe acute respiratory
                      syndrome coronavirus-2 (SARS-CoV-2) infection is associated
                      with changes in plasma levels of neurofilament light chain
                      (NfL), an extremely sensitive marker of neuroaxonal damage,
                      in community-dwelling individuals.Setting: This study was
                      embedded within the Rhineland Study, an ongoing
                      community-based cohort study in Bonn, GermanyDesign:
                      Cross-sectional nested case-control study.Participants:
                      Participants were selected based on results from a
                      previously conducted seroprevalence survey within the
                      framework of the Rhineland Study. Cases were defined as
                      those individuals who had had two positive confirmatory test
                      results, including a recombinant spike-based
                      immunofluorescence assay and a plaque reduction
                      neutralization test (N=21). As controls, a random sample of
                      individuals with a negative ELISA test result (Controls I,
                      N=1117), and those with a borderline or positive ELISA test
                      result who failed confirmatory testing (Controls II, N=68),
                      were selected.Outcome measures: Plasma levels of NfL at the
                      time of measurement, as well as change in plasma NfL levels
                      compared to previously measured pre-pandemic levelsResults:
                      After adjustment for age, sex and batch effects,
                      serologically confirmed SARS-CoV-2 infection was neither
                      associated with cross-sectional NfL levels, nor with the
                      magnitude of change from pre-pandemic levels, compared to
                      either of the two control groups. Similarly, after
                      adjustment for age, sex and batch effects, self-reported
                      neurological symptoms – including altered sense of smell
                      or taste, headache, myalgia and fever – were not
                      associated with changes in NfL levels in participants with a
                      serologically confirmed SARS-CoV-2 infection (all p ≥
                      0.56).Conclusions: Our findings indicate that
                      mild-to-moderate coronavirus disease-19 is unlikely to be
                      associated with a clinically relevant degree of neuroaxonal
                      damage, even in those cases associated with neurological
                      symptoms.},
      cin          = {AG Aziz / AG Breteler},
      cid          = {I:(DE-2719)5000071 / I:(DE-2719)1012001},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-354},
      experiment   = {EXP:(DE-2719)Rhineland Study-20190321},
      typ          = {PUB:(DE-HGF)25},
      doi          = {10.1101/2021.09.02.21263019},
      url          = {https://pub.dzne.de/record/270185},
}