Home > Publications Database > The association between SARS-CoV-2 infection and neuronal damage: A population-based nested case-control study > print |
001 | 270185 | ||
005 | 20250522160546.0 | ||
024 | 7 | _ | |a 10.1101/2021.09.02.21263019 |2 doi |
024 | 7 | _ | |a altmetric:112945343 |2 altmetric |
037 | _ | _ | |a DZNE-2024-00756 |
100 | 1 | _ | |a Aziz, N. Ahmad |0 P:(DE-2719)2812578 |b 0 |e First author |
245 | _ | _ | |a The association between SARS-CoV-2 infection and neuronal damage: A population-based nested case-control study |
260 | _ | _ | |c 2021 |
336 | 7 | _ | |a Preprint |b preprint |m preprint |0 PUB:(DE-HGF)25 |s 1747922727_14718 |2 PUB:(DE-HGF) |
336 | 7 | _ | |a WORKING_PAPER |2 ORCID |
336 | 7 | _ | |a Electronic Article |0 28 |2 EndNote |
336 | 7 | _ | |a preprint |2 DRIVER |
336 | 7 | _ | |a ARTICLE |2 BibTeX |
336 | 7 | _ | |a Output Types/Working Paper |2 DataCite |
520 | _ | _ | |a Objective: To assess whether severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is associated with changes in plasma levels of neurofilament light chain (NfL), an extremely sensitive marker of neuroaxonal damage, in community-dwelling individuals.Setting: This study was embedded within the Rhineland Study, an ongoing community-based cohort study in Bonn, GermanyDesign: Cross-sectional nested case-control study.Participants: Participants were selected based on results from a previously conducted seroprevalence survey within the framework of the Rhineland Study. Cases were defined as those individuals who had had two positive confirmatory test results, including a recombinant spike-based immunofluorescence assay and a plaque reduction neutralization test (N=21). As controls, a random sample of individuals with a negative ELISA test result (Controls I, N=1117), and those with a borderline or positive ELISA test result who failed confirmatory testing (Controls II, N=68), were selected.Outcome measures: Plasma levels of NfL at the time of measurement, as well as change in plasma NfL levels compared to previously measured pre-pandemic levelsResults: After adjustment for age, sex and batch effects, serologically confirmed SARS-CoV-2 infection was neither associated with cross-sectional NfL levels, nor with the magnitude of change from pre-pandemic levels, compared to either of the two control groups. Similarly, after adjustment for age, sex and batch effects, self-reported neurological symptoms – including altered sense of smell or taste, headache, myalgia and fever – were not associated with changes in NfL levels in participants with a serologically confirmed SARS-CoV-2 infection (all p ≥ 0.56).Conclusions: Our findings indicate that mild-to-moderate coronavirus disease-19 is unlikely to be associated with a clinically relevant degree of neuroaxonal damage, even in those cases associated with neurological symptoms. |
536 | _ | _ | |a 354 - Disease Prevention and Healthy Aging (POF4-354) |0 G:(DE-HGF)POF4-354 |c POF4-354 |f POF IV |x 0 |
588 | _ | _ | |a Dataset connected to CrossRef |
693 | _ | _ | |0 EXP:(DE-2719)Rhineland Study-20190321 |5 EXP:(DE-2719)Rhineland Study-20190321 |e Rhineland Study / Bonn |x 0 |
700 | 1 | _ | |a Santos, Marina |0 P:(DE-2719)9000737 |b 1 |
700 | 1 | _ | |a Breteler, Monique |0 P:(DE-2719)2810403 |b 2 |e Last author |
773 | _ | _ | |a 10.1101/2021.09.02.21263019 |
856 | 4 | _ | |u https://pub.dzne.de/record/270185/files/DZNE-2024-00756_Restricted.pdf |
856 | 4 | _ | |u https://pub.dzne.de/record/270185/files/DZNE-2024-00756_Restricted.pdf?subformat=pdfa |x pdfa |
909 | C | O | |p VDB |o oai:pub.dzne.de:270185 |
910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 0 |6 P:(DE-2719)2812578 |
910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 1 |6 P:(DE-2719)9000737 |
910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 2 |6 P:(DE-2719)2810403 |
913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-354 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Disease Prevention and Healthy Aging |x 0 |
920 | 1 | _ | |0 I:(DE-2719)5000071 |k AG Aziz |l Population & Clinical Neuroepidemiology |x 0 |
920 | 1 | _ | |0 I:(DE-2719)1012001 |k AG Breteler |l Population Health Sciences |x 1 |
980 | _ | _ | |a preprint |
980 | _ | _ | |a VDB |
980 | _ | _ | |a I:(DE-2719)5000071 |
980 | _ | _ | |a I:(DE-2719)1012001 |
980 | _ | _ | |a UNRESTRICTED |
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