TY  - JOUR
AU  - Salahuddin, Nurul Husna
AU  - Schütz, Alexandra
AU  - Pitschel-Walz, Gabi
AU  - Mayer, Susanna Franziska
AU  - Chaimani, Anna
AU  - Siafis, Spyridon
AU  - Priller, Josef
AU  - Leucht, Stefan
AU  - Bighelli, Irene
TI  - Psychological and psychosocial interventions for treatment-resistant schizophrenia: a systematic review and network meta-analysis
JO  - The lancet / Psychiatry
VL  - 11
IS  - 7
SN  - 2215-0366
CY  - Philadelphia, Pa.
PB  - Elsevier
M1  - DZNE-2024-00774
SP  - 545 - 553
PY  - 2024
AB  -  Many patients with schizophrenia have symptoms that do not respond to antipsychotics. This condition is called treatment-resistant schizophrenia and has not received specific attention as opposed to general schizophrenia. Psychological and psychosocial interventions as an add-on treatment to pharmacotherapy could be useful, but their role and comparative efficacy to each other and to standard care in this population are not known. We investigated the efficacy, acceptability, and tolerability of psychological and psychosocial interventions for patients with treatment-resistant schizophrenia.In this systematic review and network meta-analysis (NMA), we searched for published and unpublished randomised controlled trials (RCTs) through a systematic database search in BIOSIS, CINAHL, Embase, LILACS, MEDLINE, PsychInfo, ClinicalTrials.gov, and the WHO International Clinical Trials Registry Platform for articles published from inception up to Jan 31, 2020. We also searched the Cochrane Schizophrenia Group registry for studies published from inception up to March 31, 2022, and PubMed and Cochrane CENTRAL for studies published from inception up to July 31, 2023. We included RCTs that included patients with treatment-resistant schizophrenia. The primary outcome was overall symptoms. We did random-effects pairwise meta-analyses and NMAs to calculate standardised mean differences (SMDs) or risk ratios with 95
KW  - Humans
KW  - Network Meta-Analysis
KW  - Psychosocial Intervention: methods
KW  - Schizophrenia, Treatment-Resistant: therapy
KW  - Randomized Controlled Trials as Topic
KW  - Psychotherapy: methods
KW  - Antipsychotic Agents: therapeutic use
KW  - Treatment Outcome
KW  - Schizophrenia: therapy
KW  - Antipsychotic Agents (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:38879276
DO  - DOI:10.1016/S2215-0366(24)00136-6
UR  - https://pub.dzne.de/record/270302
ER  -