TY  - JOUR
AU  - Levin, Johannes
AU  - Baiardi, Simone
AU  - Quadalti, Corinne
AU  - Rossi, Marcello
AU  - Mammana, Angela
AU  - Vöglein, Jonathan
AU  - Bernhardt, Alexander
AU  - Perrin, Richard J
AU  - Jucker, Mathias
AU  - Preische, Oliver
AU  - Hofmann, Anna
AU  - Höglinger, Günter U
AU  - Cairns, Nigel J
AU  - Franklin, Erin E
AU  - Chrem, Patricio
AU  - Cruchaga, Carlos
AU  - Berman, Sarah B
AU  - Chhatwal, Jasmeer P
AU  - Daniels, Alisha
AU  - Day, Gregory S
AU  - Ryan, Natalie S
AU  - Goate, Alison M
AU  - Gordon, Brian A
AU  - Huey, Edward D
AU  - Ibanez, Laura
AU  - Karch, Celeste M
AU  - Lee, Jae-Hong
AU  - Llibre-Guerra, Jorge
AU  - Lopera, Francisco
AU  - Masters, Colin L
AU  - Morris, John C
AU  - Noble, James M
AU  - Renton, Alan E
AU  - Roh, Jee Hoon
AU  - Frosch, Matthew P
AU  - Keene, C Dirk
AU  - McLean, Catriona
AU  - Sanchez-Valle, Raquel
AU  - Schofield, Peter R
AU  - Supnet-Bell, Charlene
AU  - Xiong, Chengjie
AU  - Giese, Armin
AU  - Hansson, Oskar
AU  - Bateman, Randall J
AU  - McDade, Eric
AU  - Parchi, Piero
TI  - α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden.
JO  - Alzheimer's and dementia
VL  - 20
IS  - 6
SN  - 1552-5260
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2024-00783
SP  - 4351 - 4365
PY  - 2024
AB  - Amyloid beta and tau pathology are the hallmarks of sporadic Alzheimer's disease (AD) and autosomal dominant AD (ADAD). However, Lewy body pathology (LBP) is found in ≈ 50
KW  - Alzheimer Disease: diagnosis
KW  - Humans
KW  - Alzheimer Disease: genetics
KW  - Alzheimer Disease: pathology
KW  - Alzheimer Disease: cerebrospinal fluid
KW  - alpha-Synuclein: cerebrospinal fluid
KW  - alpha-Synuclein: genetics
KW  - Female
KW  - Male
KW  - Middle Aged
KW  - Lewy Bodies: pathology
KW  - Aged
KW  - Mutation
KW  - Brain: pathology
KW  - Amyloid beta-Peptides: cerebrospinal fluid
KW  - Amyloid beta-Peptides: metabolism
KW  - Disease Progression
KW  - alpha‐synuclein seed amplification assay (Other)
KW  - Dominantly Inherited Alzheimer Network (Other)
KW  - Lewy body pathology (Other)
KW  - alpha‐synuclein seed amplification assay (Other)
KW  - real‐time quaking‐induced conversion (Other)
KW  - alpha-Synuclein (NLM Chemicals)
KW  - Amyloid beta-Peptides (NLM Chemicals)
KW  - real‐time quaking‐induced conversion (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38666355
C2  - pmc:PMC11180868
DO  - DOI:10.1002/alz.13818
UR  - https://pub.dzne.de/record/270311
ER  -