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000270323 1001_ $$00000-0002-4451-4746$$aTranfa, Mario$$b0
000270323 245__ $$aAlzheimer's Disease and Small Vessel Disease Differentially Affect White Matter Microstructure.
000270323 260__ $$aChichester [u.a.]$$bWiley$$c2024
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000270323 520__ $$aAlzheimer's disease (AD) and cerebral small vessel disease (cSVD), the two most common causes of dementia, are characterized by white matter (WM) alterations diverging from the physiological changes occurring in healthy aging. Diffusion tensor imaging (DTI) is a valuable tool to quantify WM integrity non-invasively and identify the determinants of such alterations. Here, we investigated main effects and interactions of AD pathology, APOE-ε4, cSVD, and cardiovascular risk on spatial patterns of WM alterations in non-demented older adults.Within the prospective European Prevention of Alzheimer's Dementia study, we selected 606 participants (64.9 ± 7.2 years, 376 females) with baseline cerebrospinal fluid samples of amyloid β1-42 and p-Tau181 and MRI scans, including DTI scans. Longitudinal scans (mean follow-up time = 1.3 ± 0.5 years) were obtained in a subset (n = 223). WM integrity was assessed by extracting fractional anisotropy and mean diffusivity in relevant tracts. To identify the determinants of WM disruption, we performed a multimodel inference to identify the best linear mixed-effects model for each tract.AD pathology, APOE-ε4, cSVD burden, and cardiovascular risk were all associated with WM integrity within several tracts. While limbic tracts were mainly impacted by AD pathology and APOE-ε4, commissural, associative, and projection tract integrity was more related to cSVD burden and cardiovascular risk. AD pathology and cSVD did not show any significant interaction effect.Our results suggest that AD pathology and cSVD exert independent and spatially different effects on WM microstructure, supporting the role of DTI in disease monitoring and suggesting independent targets for preventive medicine approaches.
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000270323 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000270323 650_7 $$2NLM Chemicals$$aApolipoprotein E4
000270323 650_7 $$2NLM Chemicals$$atau Proteins
000270323 650_2 $$2MeSH$$aHumans
000270323 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000270323 650_2 $$2MeSH$$aAlzheimer Disease: diagnostic imaging
000270323 650_2 $$2MeSH$$aFemale
000270323 650_2 $$2MeSH$$aCerebral Small Vessel Diseases: diagnostic imaging
000270323 650_2 $$2MeSH$$aCerebral Small Vessel Diseases: pathology
000270323 650_2 $$2MeSH$$aMale
000270323 650_2 $$2MeSH$$aWhite Matter: diagnostic imaging
000270323 650_2 $$2MeSH$$aWhite Matter: pathology
000270323 650_2 $$2MeSH$$aAged
000270323 650_2 $$2MeSH$$aDiffusion Tensor Imaging
000270323 650_2 $$2MeSH$$aMiddle Aged
000270323 650_2 $$2MeSH$$aAmyloid beta-Peptides: cerebrospinal fluid
000270323 650_2 $$2MeSH$$aAmyloid beta-Peptides: metabolism
000270323 650_2 $$2MeSH$$aApolipoprotein E4: genetics
000270323 650_2 $$2MeSH$$atau Proteins: cerebrospinal fluid
000270323 650_2 $$2MeSH$$atau Proteins: metabolism
000270323 650_2 $$2MeSH$$aProspective Studies
000270323 7001_ $$aLorenzini, Luigi$$b1
000270323 7001_ $$aCollij, Lyduine E$$b2
000270323 7001_ $$aVállez García, David$$b3
000270323 7001_ $$aIngala, Silvia$$b4
000270323 7001_ $$aPontillo, Giuseppe$$b5
000270323 7001_ $$aPieperhoff, Leonard$$b6
000270323 7001_ $$00000-0002-3642-9584$$aMaranzano, Alessio$$b7
000270323 7001_ $$aWolz, Robin$$b8
000270323 7001_ $$aHaller, Sven$$b9
000270323 7001_ $$aBlennow, Kaj$$b10
000270323 7001_ $$aFrisoni, Giovanni$$b11
000270323 7001_ $$aSudre, Carole H$$b12
000270323 7001_ $$00000-0002-4889-7932$$aChételat, Gael$$b13
000270323 7001_ $$0P:(DE-2719)9000543$$aEwers, Michael$$b14
000270323 7001_ $$aPayoux, Pierre$$b15
000270323 7001_ $$aWaldman, Adam$$b16
000270323 7001_ $$00000-0001-5404-9967$$aMartinez-Lage, Pablo$$b17
000270323 7001_ $$aSchwarz, Adam J$$b18
000270323 7001_ $$aRitchie, Craig W$$b19
000270323 7001_ $$00000-0002-9812-6642$$aWardlaw, Joanna M$$b20
000270323 7001_ $$aGispert, Juan Domingo$$b21
000270323 7001_ $$aBrunetti, Arturo$$b22
000270323 7001_ $$00000-0003-0894-0307$$aMutsaerts, Henk J M M$$b23
000270323 7001_ $$aWink, Alle Meije$$b24
000270323 7001_ $$aBarkhof, Frederik$$b25
000270323 773__ $$0PERI:(DE-600)2740696-9$$a10.1002/acn3.52071$$gVol. 11, no. 6, p. 1541 - 1556$$n6$$p1541 - 1556$$tAnnals of Clinical and Translational Neurology$$v11$$x2328-9503$$y2024
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