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000270413 037__ $$aDZNE-2024-00793
000270413 041__ $$aEnglish
000270413 082__ $$a610
000270413 1001_ $$0P:(DE-2719)9000315$$aUkmar-Godec, Tina$$b0$$eFirst author
000270413 245__ $$aConformational diversity of human HP1α.
000270413 260__ $$aBethesda, Md.$$bProtein Society$$c2024
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000270413 520__ $$aHeterochromatin protein 1 alpha (HP1α) is an evolutionarily conserved protein that binds chromatin and is important for gene silencing. The protein comprises 191 residues arranged into three disordered regions and two structured domains, the chromo and chromoshadow domain, which associates into a homodimer. While high-resolution structures of the isolated domains of HP1 proteins are known, the structural properties of full-length HP1α remain largely unknown. Using a combination of NMR spectroscopy and structure predictions by AlphaFold2 we provide evidence that the chromo and chromoshadow domain of HP1α engage in direct contacts resulting in a compact chromo/chromoshadow domain arrangement. We further show that HP1β and HP1γ have increased interdomain dynamics when compared to HP1α which may contribute to the distinct roles of different Hp1 isoforms in gene silencing and activation.
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000270413 650_2 $$2MeSH$$aChromobox Protein Homolog 5: chemistry
000270413 650_2 $$2MeSH$$aChromosomal Proteins, Non-Histone: chemistry
000270413 650_2 $$2MeSH$$aChromosomal Proteins, Non-Histone: genetics
000270413 650_2 $$2MeSH$$aChromosomal Proteins, Non-Histone: metabolism
000270413 650_2 $$2MeSH$$aHumans
000270413 650_2 $$2MeSH$$aModels, Molecular
000270413 650_2 $$2MeSH$$aNuclear Magnetic Resonance, Biomolecular
000270413 650_2 $$2MeSH$$aProtein Domains
000270413 650_2 $$2MeSH$$aProtein Conformation
000270413 650_7 $$2Other$$aHP1α
000270413 650_7 $$2Other$$aAlphaFold
000270413 650_7 $$2Other$$aHP1α
000270413 650_7 $$2Other$$aNMR spectroscopy
000270413 650_7 $$2Other$$achromatin
000270413 650_7 $$2Other$$adynamics
000270413 650_7 $$2Other$$aresidual dipolar couplings
000270413 650_7 $$0107283-02-3$$2NLM Chemicals$$aChromobox Protein Homolog 5
000270413 650_7 $$2NLM Chemicals$$aChromosomal Proteins, Non-Histone
000270413 650_7 $$2NLM Chemicals$$aCBX5 protein, human
000270413 7001_ $$0P:(DE-2719)2811447$$aYu, Taekyung$$b1$$udzne
000270413 7001_ $$0P:(DE-2719)2812657$$aIbanez de Opakua, Alain$$b2$$udzne
000270413 7001_ $$0P:(DE-2719)2812808$$aPantoja, Christian F$$b3$$udzne
000270413 7001_ $$0P:(DE-2719)2810686$$aMunari, Francesca$$b4
000270413 7001_ $$0P:(DE-2719)2810591$$aZweckstetter, Markus$$b5$$eLast author$$udzne
000270413 773__ $$0PERI:(DE-600)2000025-X$$a10.1002/pro.5079$$gVol. 33, no. 7, p. e5079$$n7$$pe5079$$tProtein science$$v33$$x0961-8368$$y2024
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