Home > Publications Database > Conformational diversity of human HP1α. > print

001     270413
005     20240808164309.0
024 7 _ |a 10.1002/pro.5079
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024 7 _ |a 0961-8368
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024 7 _ |a 1469-896X
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037 _ _ |a DZNE-2024-00793
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Ukmar-Godec, Tina
|0 P:(DE-2719)9000315
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245 _ _ |a Conformational diversity of human HP1α.
260 _ _ |a Bethesda, Md.
|c 2024
|b Protein Society
336 7 _ |a article
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336 7 _ |a ARTICLE
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520 _ _ |a Heterochromatin protein 1 alpha (HP1α) is an evolutionarily conserved protein that binds chromatin and is important for gene silencing. The protein comprises 191 residues arranged into three disordered regions and two structured domains, the chromo and chromoshadow domain, which associates into a homodimer. While high-resolution structures of the isolated domains of HP1 proteins are known, the structural properties of full-length HP1α remain largely unknown. Using a combination of NMR spectroscopy and structure predictions by AlphaFold2 we provide evidence that the chromo and chromoshadow domain of HP1α engage in direct contacts resulting in a compact chromo/chromoshadow domain arrangement. We further show that HP1β and HP1γ have increased interdomain dynamics when compared to HP1α which may contribute to the distinct roles of different Hp1 isoforms in gene silencing and activation.
536 _ _ |a 352 - Disease Mechanisms (POF4-352)
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650 _ 2 |a Chromobox Protein Homolog 5: chemistry
|2 MeSH
650 _ 2 |a Chromosomal Proteins, Non-Histone: chemistry
|2 MeSH
650 _ 2 |a Chromosomal Proteins, Non-Histone: genetics
|2 MeSH
650 _ 2 |a Chromosomal Proteins, Non-Histone: metabolism
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Models, Molecular
|2 MeSH
650 _ 2 |a Nuclear Magnetic Resonance, Biomolecular
|2 MeSH
650 _ 2 |a Protein Domains
|2 MeSH
650 _ 2 |a Protein Conformation
|2 MeSH
650 _ 7 |a HP1α
|2 Other
650 _ 7 |a AlphaFold
|2 Other
650 _ 7 |a HP1α
|2 Other
650 _ 7 |a NMR spectroscopy
|2 Other
650 _ 7 |a chromatin
|2 Other
650 _ 7 |a dynamics
|2 Other
650 _ 7 |a residual dipolar couplings
|2 Other
650 _ 7 |a Chromobox Protein Homolog 5
|0 107283-02-3
|2 NLM Chemicals
650 _ 7 |a Chromosomal Proteins, Non-Histone
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650 _ 7 |a CBX5 protein, human
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700 1 _ |a Yu, Taekyung
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700 1 _ |a Ibanez de Opakua, Alain
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700 1 _ |a Pantoja, Christian F
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700 1 _ |a Munari, Francesca
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|b 4
700 1 _ |a Zweckstetter, Markus
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773 _ _ |a 10.1002/pro.5079
|g Vol. 33, no. 7, p. e5079
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|t Protein science
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856 4 _ |y OpenAccess
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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