%0 Journal Article
%A Domenighetti, Cloé
%A Sugier, Pierre-Emmanuel
%A Ashok Kumar Sreelatha, Ashwin
%A Schulte, Claudia
%A Grover, Sandeep
%A Portugal, Berta
%A Lee, Pei-Chen
%A May, Patrick
%A Bobbili, Dheeraj
%A Radivojkov Blagojevic, Milena
%A Lichtner, Peter
%A Singleton, Andrew B
%A Hernandez, Dena
%A Edsall, Connor
%A Mellick, George D
%A Zimprich, Alexander A
%A Pirker, Walter
%A Rogaeva, Ekaterina A
%A Lang, Anthony E
%A Koks, Sulev
%A Taba, Pille
%A Lesage, Suzanne
%A Brice, Alexis
%A Corvol, Jean-Christophe
%A Chartier-Harlin, Marie-Christine
%A Mutez, Eugenie
%A Brockmann, Kathrin
%A Deutschlander, Angela B
%A Hadjigeorgiou, Georgios M
%A Dardiotis, Efthimios
%A Stefanis, Leonidas
%A Simitsi, Athina Maria
%A Valente, Enza Maria
%A Petrucci, Simona
%A Straniero, Letizia
%A Zecchinelli, Anna L
%A Pezzoli, Gianni
%A Brighina, Laura
%A Ferrarese, Carlo
%A Annesi, Grazia
%A Quattrone, Andrea
%A Gagliardi, Monica
%A Matsuo, Hirotaka
%A Nakayama, Akiyoshi
%A Hattori, Nobutaka
%A Nishioka, Kenya
%A Chung, Sun Ju
%A Kim, Yun Joong
%A Kolber, Pierre
%A Van De Warrenburg, Bart P C
%A Bloem, Bastiaan R
%A Toft, Mathias
%A Pihlstrøm, Lasse
%A Correia Guedes, Leonor
%A Ferreira, Joaquim J
%A Bardien, Soraya
%A Carr, Jonathan
%A Tolosa, Eduardo
%A Ezquerra, Mario
%A Pastor, Pau
%A Diez-Fairen, Monica
%A Wirdefeldt, Karin
%A Pedersen, Nancy L
%A Ran, Caroline
%A Belin, Andrea C
%A Puschmann, Andreas
%A Hellberg, Clara
%A Clarke, Carl E
%A Morrison, Karen E
%A Tan, Manuela M
%A Krainc, Dimitri
%A Burbulla, Lena F.
%A Farrer, Matthew
%A Krüger, Rejko
%A Gasser, Thomas
%A Sharma, Manu
%A Elbaz, Alexis
%A Genetics, Comprehensive Unbiased Risk Factor Assessment for
%T Association of Body Mass Index and Parkinson Disease: A Bidirectional Mendelian Randomization Study.
%J Neurology
%V 103
%N 3
%@ 0028-3878
%C [Erscheinungsort nicht ermittelbar]
%I Ovid
%M DZNE-2024-00803
%P e209620
%D 2024
%X The role of body mass index (BMI) in Parkinson disease (PD) is unclear. Based on the Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in PD (Courage-PD) consortium, we used 2-sample Mendelian randomization (MR) to replicate a previously reported inverse association of genetically predicted BMI with PD and investigated whether findings were robust in analyses addressing the potential for survival and incidence-prevalence biases. We also examined whether the BMI-PD relation is bidirectional by performing a reverse MR.We used summary statistics from a genome-wide association study (GWAS) to extract the association of 501 single-nucleotide polymorphisms (SNPs) with BMI and from the Courage-PD and international Parkinson Disease Genomics Consortium (iPDGC) to estimate their association with PD. Analyses are based on participants of European ancestry. We used the inverse-weighted method to compute odds ratios (ORIVW per 4.8 kg/m2 [95
%K Humans
%K Mendelian Randomization Analysis
%K Parkinson Disease: genetics
%K Parkinson Disease: epidemiology
%K Body Mass Index
%K Polymorphism, Single Nucleotide: genetics
%K Female
%K Male
%K Genome-Wide Association Study
%K Middle Aged
%K Aged
%K Risk Factors
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38986057
%R 10.1212/WNL.0000000000209620
%U https://pub.dzne.de/record/270631