%0 Journal Article
%A Bendella, Zeynep
%A Purrer, Veronika
%A Haase, Robert
%A Zülow, Stefan
%A Kindler, Christine
%A Borger, Valerie
%A Banat, Mohammed
%A Dorn, Franziska
%A Wüllner, Ullrich
%A Radbruch, Alexander
%A Schmeel, Frederic Carsten
%T Brain and Ventricle Volume Alterations in Idiopathic Normal Pressure Hydrocephalus Determined by Artificial Intelligence-Based MRI Volumetry.
%J Diagnostics
%V 14
%N 13
%@ 2075-4418
%C Basel
%I MDPI
%M DZNE-2024-00811
%P 1422
%D 2024
%X The aim of this study was to employ artificial intelligence (AI)-based magnetic resonance imaging (MRI) brain volumetry to potentially distinguish between idiopathic normal pressure hydrocephalus (iNPH), Alzheimer's disease (AD), and age- and sex-matched healthy controls (CG) by evaluating cortical, subcortical, and ventricular volumes. Additionally, correlations between the measured brain and ventricle volumes and two established semi-quantitative radiologic markers for iNPH were examined. An IRB-approved retrospective analysis was conducted on 123 age- and sex-matched subjects (41 iNPH, 41 AD, and 41 controls), with all of the iNPH patients undergoing routine clinical brain MRI prior to ventriculoperitoneal shunt implantation. Automated AI-based determination of different cortical and subcortical brain and ventricular volumes in mL, as well as calculation of population-based normalized percentiles according to an embedded database, was performed; the CE-certified software mdbrain v4.4.1 or above was used with a standardized T1-weighted 3D magnetization-prepared rapid gradient echo (MPRAGE) sequence. Measured brain volumes and percentiles were analyzed for between-group differences and correlated with semi-quantitative measurements of the Evans' index and corpus callosal angle: iNPH patients exhibited ventricular enlargement and changes in gray and white matter compared to AD patients and controls, with the most significant differences observed in total ventricular volume (+67
%K automated volumetrization (Other)
%K brain atrophy (Other)
%K normal pressure hydrocephalus (Other)
%K quantitative neuroimaging (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39001312
%2 pmc:PMC11241572
%R 10.3390/diagnostics14131422
%U https://pub.dzne.de/record/270639