TY  - JOUR
AU  - Bendella, Zeynep
AU  - Purrer, Veronika
AU  - Haase, Robert
AU  - Zülow, Stefan
AU  - Kindler, Christine
AU  - Borger, Valerie
AU  - Banat, Mohammed
AU  - Dorn, Franziska
AU  - Wüllner, Ullrich
AU  - Radbruch, Alexander
AU  - Schmeel, Frederic Carsten
TI  - Brain and Ventricle Volume Alterations in Idiopathic Normal Pressure Hydrocephalus Determined by Artificial Intelligence-Based MRI Volumetry.
JO  - Diagnostics
VL  - 14
IS  - 13
SN  - 2075-4418
CY  - Basel
PB  - MDPI
M1  - DZNE-2024-00811
SP  - 1422
PY  - 2024
AB  - The aim of this study was to employ artificial intelligence (AI)-based magnetic resonance imaging (MRI) brain volumetry to potentially distinguish between idiopathic normal pressure hydrocephalus (iNPH), Alzheimer's disease (AD), and age- and sex-matched healthy controls (CG) by evaluating cortical, subcortical, and ventricular volumes. Additionally, correlations between the measured brain and ventricle volumes and two established semi-quantitative radiologic markers for iNPH were examined. An IRB-approved retrospective analysis was conducted on 123 age- and sex-matched subjects (41 iNPH, 41 AD, and 41 controls), with all of the iNPH patients undergoing routine clinical brain MRI prior to ventriculoperitoneal shunt implantation. Automated AI-based determination of different cortical and subcortical brain and ventricular volumes in mL, as well as calculation of population-based normalized percentiles according to an embedded database, was performed; the CE-certified software mdbrain v4.4.1 or above was used with a standardized T1-weighted 3D magnetization-prepared rapid gradient echo (MPRAGE) sequence. Measured brain volumes and percentiles were analyzed for between-group differences and correlated with semi-quantitative measurements of the Evans' index and corpus callosal angle: iNPH patients exhibited ventricular enlargement and changes in gray and white matter compared to AD patients and controls, with the most significant differences observed in total ventricular volume (+67
KW  - automated volumetrization (Other)
KW  - brain atrophy (Other)
KW  - normal pressure hydrocephalus (Other)
KW  - quantitative neuroimaging (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39001312
C2  - pmc:PMC11241572
DO  - DOI:10.3390/diagnostics14131422
UR  - https://pub.dzne.de/record/270639
ER  -