%0 Journal Article
%A Purrer, Veronika
%A Pohl, Emily
%A Borger, Valeri
%A Weiland, Hannah
%A Boecker, Henning
%A Schmeel, Frederic Carsten
%A Wüllner, Ullrich
%T Motor and non-motor outcome in tremor dominant Parkinson's disease after MR-guided focused ultrasound thalamotomy.
%J Journal of neurology
%V 271
%N 7
%@ 0367-004X
%C Heidelberg
%I Springer
%M DZNE-2024-00827
%P 3731 - 3742
%D 2024
%X Magnetic Resonance-guided Focused Ultrasound (MRgFUS) is an emerging technique for the treatment of severe, medication-refractory tremor syndromes. We here report motor and non-motor outcomes 6 and 12 months after unilateral MRgFUS thalamotomy in tremor-dominant Parkinson's disease (tdPD).25 patients with tdPD underwent neuropsychological evaluation including standardized questionnaires of disability, quality of life (QoL), mood, anxiety, apathy, sleep disturbances, and cognition at baseline, 6 and 12 months after MRgFUS. Motor outcome was evaluated using the Clinical Rating Scale for Tremor (CRST) and Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS). In addition, side effects and QoL of family caregivers were assessed.12 months after MRgFUS significant improvements were evident in the tremor subscores. Patients with concomitant rest and postural tremor showed better tremor outcomes compared to patients with predominant rest tremor. There were no differences in the non-motor assessments. No cognitive decline was observed. Side effects were mostly transient (54
%K Humans
%K Male
%K Parkinson Disease: therapy
%K Parkinson Disease: complications
%K Parkinson Disease: surgery
%K Female
%K Tremor: etiology
%K Tremor: diagnostic imaging
%K Tremor: therapy
%K Tremor: surgery
%K Aged
%K Middle Aged
%K Thalamus: diagnostic imaging
%K Thalamus: surgery
%K Quality of Life
%K Treatment Outcome
%K Magnetic Resonance Imaging
%K Parkinson’s disease (Other)
%K Focused ultrasound (Other)
%K Non-motor symptoms (Other)
%K Parkinson’s disease (Other)
%K Thalamotomy (Other)
%K Tremor (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38822147
%2 pmc:PMC11233288
%R 10.1007/s00415-024-12469-z
%U https://pub.dzne.de/record/270655