TY  - JOUR
AU  - Purrer, Veronika
AU  - Pohl, Emily
AU  - Borger, Valeri
AU  - Weiland, Hannah
AU  - Boecker, Henning
AU  - Schmeel, Frederic Carsten
AU  - Wüllner, Ullrich
TI  - Motor and non-motor outcome in tremor dominant Parkinson's disease after MR-guided focused ultrasound thalamotomy.
JO  - Journal of neurology
VL  - 271
IS  - 7
SN  - 0367-004X
CY  - Heidelberg
PB  - Springer
M1  - DZNE-2024-00827
SP  - 3731 - 3742
PY  - 2024
AB  - Magnetic Resonance-guided Focused Ultrasound (MRgFUS) is an emerging technique for the treatment of severe, medication-refractory tremor syndromes. We here report motor and non-motor outcomes 6 and 12 months after unilateral MRgFUS thalamotomy in tremor-dominant Parkinson's disease (tdPD).25 patients with tdPD underwent neuropsychological evaluation including standardized questionnaires of disability, quality of life (QoL), mood, anxiety, apathy, sleep disturbances, and cognition at baseline, 6 and 12 months after MRgFUS. Motor outcome was evaluated using the Clinical Rating Scale for Tremor (CRST) and Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS). In addition, side effects and QoL of family caregivers were assessed.12 months after MRgFUS significant improvements were evident in the tremor subscores. Patients with concomitant rest and postural tremor showed better tremor outcomes compared to patients with predominant rest tremor. There were no differences in the non-motor assessments. No cognitive decline was observed. Side effects were mostly transient (54
KW  - Humans
KW  - Male
KW  - Parkinson Disease: therapy
KW  - Parkinson Disease: complications
KW  - Parkinson Disease: surgery
KW  - Female
KW  - Tremor: etiology
KW  - Tremor: diagnostic imaging
KW  - Tremor: therapy
KW  - Tremor: surgery
KW  - Aged
KW  - Middle Aged
KW  - Thalamus: diagnostic imaging
KW  - Thalamus: surgery
KW  - Quality of Life
KW  - Treatment Outcome
KW  - Magnetic Resonance Imaging
KW  - Parkinson’s disease (Other)
KW  - Focused ultrasound (Other)
KW  - Non-motor symptoms (Other)
KW  - Parkinson’s disease (Other)
KW  - Thalamotomy (Other)
KW  - Tremor (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38822147
C2  - pmc:PMC11233288
DO  - DOI:10.1007/s00415-024-12469-z
UR  - https://pub.dzne.de/record/270655
ER  -