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@ARTICLE{Purrer:270655,
      author       = {Purrer, Veronika and Pohl, Emily and Borger, Valeri and
                      Weiland, Hannah and Boecker, Henning and Schmeel, Frederic
                      Carsten and Wüllner, Ullrich},
      title        = {{M}otor and non-motor outcome in tremor dominant
                      {P}arkinson's disease after {MR}-guided focused ultrasound
                      thalamotomy.},
      journal      = {Journal of neurology},
      volume       = {271},
      number       = {7},
      issn         = {0367-004X},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DZNE-2024-00827},
      pages        = {3731 - 3742},
      year         = {2024},
      abstract     = {Magnetic Resonance-guided Focused Ultrasound (MRgFUS) is an
                      emerging technique for the treatment of severe,
                      medication-refractory tremor syndromes. We here report motor
                      and non-motor outcomes 6 and 12 months after unilateral
                      MRgFUS thalamotomy in tremor-dominant Parkinson's disease
                      (tdPD).25 patients with tdPD underwent neuropsychological
                      evaluation including standardized questionnaires of
                      disability, quality of life (QoL), mood, anxiety, apathy,
                      sleep disturbances, and cognition at baseline, 6 and 12
                      months after MRgFUS. Motor outcome was evaluated using the
                      Clinical Rating Scale for Tremor (CRST) and Movement
                      Disorder Society-Unified Parkinson's Disease Rating Scale
                      (MDS-UPDRS). In addition, side effects and QoL of family
                      caregivers were assessed.12 months after MRgFUS significant
                      improvements were evident in the tremor subscores. Patients
                      with concomitant rest and postural tremor showed better
                      tremor outcomes compared to patients with predominant rest
                      tremor. There were no differences in the non-motor
                      assessments. No cognitive decline was observed. Side effects
                      were mostly transient $(54\%)$ and classified as mild
                      $(62\%).$ No changes in the caregivers' QoL could be
                      observed.We found no changes in mood, anxiety, apathy,
                      sleep, cognition or persistent worsening of gait
                      disturbances after unilateral MRgFUS thalamotomy in tdPD.
                      Concomitant postural tremors responded better to treatment
                      than predominant rest tremors.},
      keywords     = {Humans / Male / Parkinson Disease: therapy / Parkinson
                      Disease: complications / Parkinson Disease: surgery / Female
                      / Tremor: etiology / Tremor: diagnostic imaging / Tremor:
                      therapy / Tremor: surgery / Aged / Middle Aged / Thalamus:
                      diagnostic imaging / Thalamus: surgery / Quality of Life /
                      Treatment Outcome / Magnetic Resonance Imaging /
                      Parkinson’s disease (Other) / Focused ultrasound (Other) /
                      Non-motor symptoms (Other) / Parkinson’s disease (Other) /
                      Thalamotomy (Other) / Tremor (Other)},
      cin          = {AG Wüllner / AG Klockgether / AG Boecker},
      ddc          = {610},
      cid          = {I:(DE-2719)1011302 / I:(DE-2719)1011001 /
                      I:(DE-2719)1011202},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38822147},
      pmc          = {pmc:PMC11233288},
      doi          = {10.1007/s00415-024-12469-z},
      url          = {https://pub.dzne.de/record/270655},
}