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000270678 1001_ $$0P:(DE-2719)2812844$$aWiesner, Diana$$b0$$eFirst author$$udzne
000270678 245__ $$aNeuropeptide FF (NPFF)-positive nerve cells of the human cerebral cortex and white matter in controls, selected neurodegenerative diseases, and schizophrenia.
000270678 260__ $$aLondon$$bBiomed Central$$c2024
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000270678 520__ $$aWe quantified and determined for the first time the distribution pattern of the neuropeptide NPFF in the human cerebral cortex and subjacent white matter. To do so, we studied n = 9 cases without neurological disorders and n = 22 cases with neurodegenerative diseases, including sporadic amyotrophic lateral sclerosis (ALS, n = 8), Alzheimer's disease (AD, n = 8), Pick's disease (PiD, n = 3), and schizophrenia (n = 3). NPFF-immunopositive cells were located chiefly, but not exclusively, in the superficial white matter and constituted there a subpopulation of white matter interstitial cells (WMIC): Pyramidal-like and multipolar somata predominated in the gyral crowns, whereas bipolar and ovoid somata predominated in the cortex surrounding the sulci. Their sparsely ramified axons were unmyelinated and exhibited NPFF-positive bead-like varicosities. We found significantly fewer NPFF-immunopositive cells in the gray matter of the frontal, cingulate, and superior temporal gyri of both sporadic ALS and late-stage AD patients than in controls, and significantly fewer NPFF-positive cells in the subjacent as well as deep white matter of the frontal gyrus of these patients compared to controls. Notably, the number of NPFF-positive cells was also significantly lower in the hippocampal formation in AD compared to controls. In PiD, NPFF-positive cells were present in significantly lower numbers in the gray and white matter of the cingulate and frontal gyrii in comparison to controls. In schizophrenic patients, lower wNPFF cell counts in the neocortex were significant and global (cingulate, frontal, superior temporal gyrus, medial, and inferior gyri). The precise functions of NPFF-positive cells and their relationship to the superficial corticocortical white matter U-fibers are currently unknown. Here, NPFF immunohistochemistry and expression characterize a previously unrecognized population of cells in the human brain, thereby providing a new entry-point for investigating their physiological and pathophysiological roles.
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000270678 650_2 $$2MeSH$$aHumans
000270678 650_2 $$2MeSH$$aWhite Matter: pathology
000270678 650_2 $$2MeSH$$aWhite Matter: metabolism
000270678 650_2 $$2MeSH$$aMale
000270678 650_2 $$2MeSH$$aSchizophrenia: pathology
000270678 650_2 $$2MeSH$$aSchizophrenia: metabolism
000270678 650_2 $$2MeSH$$aFemale
000270678 650_2 $$2MeSH$$aCerebral Cortex: pathology
000270678 650_2 $$2MeSH$$aCerebral Cortex: metabolism
000270678 650_2 $$2MeSH$$aAged
000270678 650_2 $$2MeSH$$aMiddle Aged
000270678 650_2 $$2MeSH$$aNeurodegenerative Diseases: pathology
000270678 650_2 $$2MeSH$$aNeurodegenerative Diseases: metabolism
000270678 650_2 $$2MeSH$$aAged, 80 and over
000270678 650_2 $$2MeSH$$aOligopeptides
000270678 650_2 $$2MeSH$$aAdult
000270678 650_2 $$2MeSH$$aNeurons: pathology
000270678 650_2 $$2MeSH$$aNeurons: metabolism
000270678 650_7 $$2Other$$aAlzheimer’s disease
000270678 650_7 $$2Other$$aAlzheimer’s disease
000270678 650_7 $$2Other$$aAmyotrophic lateral sclerosis
000270678 650_7 $$2Other$$aCerebral cortex
000270678 650_7 $$2Other$$aHuman brain
000270678 650_7 $$2Other$$aInterneurons
000270678 650_7 $$2Other$$aNOS (type I)
000270678 650_7 $$2Other$$aNeurodegeneration
000270678 650_7 $$2Other$$aNeuropeptide FF (NPFF)
000270678 650_7 $$2Other$$aPick’s disease
000270678 650_7 $$2Other$$aSchizophrenia
000270678 650_7 $$2Other$$aSomatostatin
000270678 650_7 $$2Other$$aU-fibers
000270678 650_7 $$2Other$$aWhite matter interstitial cells
000270678 650_7 $$099566-27-5$$2NLM Chemicals$$aphenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide
000270678 650_7 $$2NLM Chemicals$$aOligopeptides
000270678 650_7 $$2Other$$aPick’s disease
000270678 7001_ $$0P:(DE-HGF)0$$aFeldengut, Simone$$b1
000270678 7001_ $$0P:(DE-HGF)0$$aWoelfle, Sarah$$b2
000270678 7001_ $$0P:(DE-2719)2812855$$aBoeckers, Tobias M$$b3$$udzne
000270678 7001_ $$0P:(DE-2719)2812633$$aLudolph, Albert C$$b4$$udzne
000270678 7001_ $$0P:(DE-2719)2812851$$aRoselli, Francesco$$b5
000270678 7001_ $$0P:(DE-HGF)0$$aDel Tredici, Kelly$$b6
000270678 773__ $$0PERI:(DE-600)2715589-4$$a10.1186/s40478-024-01792-1$$gVol. 12, no. 1, p. 108$$n1$$p108$$tActa Neuropathologica Communications$$v12$$x2051-5960$$y2024
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