TY  - JOUR
AU  - Wiesner, Diana
AU  - Feldengut, Simone
AU  - Woelfle, Sarah
AU  - Boeckers, Tobias M
AU  - Ludolph, Albert C
AU  - Roselli, Francesco
AU  - Del Tredici, Kelly
TI  - Neuropeptide FF (NPFF)-positive nerve cells of the human cerebral cortex and white matter in controls, selected neurodegenerative diseases, and schizophrenia.
JO  - Acta Neuropathologica Communications
VL  - 12
IS  - 1
SN  - 2051-5960
CY  - London
PB  - Biomed Central
M1  - DZNE-2024-00850
SP  - 108
PY  - 2024
AB  - We quantified and determined for the first time the distribution pattern of the neuropeptide NPFF in the human cerebral cortex and subjacent white matter. To do so, we studied n = 9 cases without neurological disorders and n = 22 cases with neurodegenerative diseases, including sporadic amyotrophic lateral sclerosis (ALS, n = 8), Alzheimer's disease (AD, n = 8), Pick's disease (PiD, n = 3), and schizophrenia (n = 3). NPFF-immunopositive cells were located chiefly, but not exclusively, in the superficial white matter and constituted there a subpopulation of white matter interstitial cells (WMIC): Pyramidal-like and multipolar somata predominated in the gyral crowns, whereas bipolar and ovoid somata predominated in the cortex surrounding the sulci. Their sparsely ramified axons were unmyelinated and exhibited NPFF-positive bead-like varicosities. We found significantly fewer NPFF-immunopositive cells in the gray matter of the frontal, cingulate, and superior temporal gyri of both sporadic ALS and late-stage AD patients than in controls, and significantly fewer NPFF-positive cells in the subjacent as well as deep white matter of the frontal gyrus of these patients compared to controls. Notably, the number of NPFF-positive cells was also significantly lower in the hippocampal formation in AD compared to controls. In PiD, NPFF-positive cells were present in significantly lower numbers in the gray and white matter of the cingulate and frontal gyrii in comparison to controls. In schizophrenic patients, lower wNPFF cell counts in the neocortex were significant and global (cingulate, frontal, superior temporal gyrus, medial, and inferior gyri). The precise functions of NPFF-positive cells and their relationship to the superficial corticocortical white matter U-fibers are currently unknown. Here, NPFF immunohistochemistry and expression characterize a previously unrecognized population of cells in the human brain, thereby providing a new entry-point for investigating their physiological and pathophysiological roles.
KW  - Humans
KW  - White Matter: pathology
KW  - White Matter: metabolism
KW  - Male
KW  - Schizophrenia: pathology
KW  - Schizophrenia: metabolism
KW  - Female
KW  - Cerebral Cortex: pathology
KW  - Cerebral Cortex: metabolism
KW  - Aged
KW  - Middle Aged
KW  - Neurodegenerative Diseases: pathology
KW  - Neurodegenerative Diseases: metabolism
KW  - Aged, 80 and over
KW  - Oligopeptides
KW  - Adult
KW  - Neurons: pathology
KW  - Neurons: metabolism
KW  - Alzheimer’s disease (Other)
KW  - Alzheimer’s disease (Other)
KW  - Amyotrophic lateral sclerosis (Other)
KW  - Cerebral cortex (Other)
KW  - Human brain (Other)
KW  - Interneurons (Other)
KW  - NOS (type I) (Other)
KW  - Neurodegeneration (Other)
KW  - Neuropeptide FF (NPFF) (Other)
KW  - Pick’s disease (Other)
KW  - Schizophrenia (Other)
KW  - Somatostatin (Other)
KW  - U-fibers (Other)
KW  - White matter interstitial cells (Other)
KW  - phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide (NLM Chemicals)
KW  - Oligopeptides (NLM Chemicals)
KW  - Pick’s disease (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38943180
C2  - pmc:PMC11212262
DO  - DOI:10.1186/s40478-024-01792-1
UR  - https://pub.dzne.de/record/270678
ER  -