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@ARTICLE{Wiesner:270678,
      author       = {Wiesner, Diana and Feldengut, Simone and Woelfle, Sarah and
                      Boeckers, Tobias M and Ludolph, Albert C and Roselli,
                      Francesco and Del Tredici, Kelly},
      title        = {{N}europeptide {FF} ({NPFF})-positive nerve cells of the
                      human cerebral cortex and white matter in controls, selected
                      neurodegenerative diseases, and schizophrenia.},
      journal      = {Acta Neuropathologica Communications},
      volume       = {12},
      number       = {1},
      issn         = {2051-5960},
      address      = {London},
      publisher    = {Biomed Central},
      reportid     = {DZNE-2024-00850},
      pages        = {108},
      year         = {2024},
      abstract     = {We quantified and determined for the first time the
                      distribution pattern of the neuropeptide NPFF in the human
                      cerebral cortex and subjacent white matter. To do so, we
                      studied n = 9 cases without neurological disorders and n =
                      22 cases with neurodegenerative diseases, including sporadic
                      amyotrophic lateral sclerosis (ALS, n = 8), Alzheimer's
                      disease (AD, n = 8), Pick's disease (PiD, n = 3), and
                      schizophrenia (n = 3). NPFF-immunopositive cells were
                      located chiefly, but not exclusively, in the superficial
                      white matter and constituted there a subpopulation of white
                      matter interstitial cells (WMIC): Pyramidal-like and
                      multipolar somata predominated in the gyral crowns, whereas
                      bipolar and ovoid somata predominated in the cortex
                      surrounding the sulci. Their sparsely ramified axons were
                      unmyelinated and exhibited NPFF-positive bead-like
                      varicosities. We found significantly fewer
                      NPFF-immunopositive cells in the gray matter of the frontal,
                      cingulate, and superior temporal gyri of both sporadic ALS
                      and late-stage AD patients than in controls, and
                      significantly fewer NPFF-positive cells in the subjacent as
                      well as deep white matter of the frontal gyrus of these
                      patients compared to controls. Notably, the number of
                      NPFF-positive cells was also significantly lower in the
                      hippocampal formation in AD compared to controls. In PiD,
                      NPFF-positive cells were present in significantly lower
                      numbers in the gray and white matter of the cingulate and
                      frontal gyrii in comparison to controls. In schizophrenic
                      patients, lower wNPFF cell counts in the neocortex were
                      significant and global (cingulate, frontal, superior
                      temporal gyrus, medial, and inferior gyri). The precise
                      functions of NPFF-positive cells and their relationship to
                      the superficial corticocortical white matter U-fibers are
                      currently unknown. Here, NPFF immunohistochemistry and
                      expression characterize a previously unrecognized population
                      of cells in the human brain, thereby providing a new
                      entry-point for investigating their physiological and
                      pathophysiological roles.},
      keywords     = {Humans / White Matter: pathology / White Matter: metabolism
                      / Male / Schizophrenia: pathology / Schizophrenia:
                      metabolism / Female / Cerebral Cortex: pathology / Cerebral
                      Cortex: metabolism / Aged / Middle Aged / Neurodegenerative
                      Diseases: pathology / Neurodegenerative Diseases: metabolism
                      / Aged, 80 and over / Oligopeptides / Adult / Neurons:
                      pathology / Neurons: metabolism / Alzheimer’s disease
                      (Other) / Alzheimer’s disease (Other) / Amyotrophic
                      lateral sclerosis (Other) / Cerebral cortex (Other) / Human
                      brain (Other) / Interneurons (Other) / NOS (type I) (Other)
                      / Neurodegeneration (Other) / Neuropeptide FF (NPFF) (Other)
                      / Pick’s disease (Other) / Schizophrenia (Other) /
                      Somatostatin (Other) / U-fibers (Other) / White matter
                      interstitial cells (Other) /
                      phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide
                      (NLM Chemicals) / Oligopeptides (NLM Chemicals) / Pick’s
                      disease (Other)},
      cin          = {AG Roselli / AG Böckers / Clinical Study Center Ulm ;
                      Clinical Study Center (Ulm)},
      ddc          = {610},
      cid          = {I:(DE-2719)1910001 / I:(DE-2719)1910002 /
                      I:(DE-2719)5000077},
      pnm          = {352 - Disease Mechanisms (POF4-352) / 353 - Clinical and
                      Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-352 / G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38943180},
      pmc          = {pmc:PMC11212262},
      doi          = {10.1186/s40478-024-01792-1},
      url          = {https://pub.dzne.de/record/270678},
}