%0 Journal Article
%A Talevi, Valentina
%A Melas, Konstantinos
%A Pehlivan, Gökhan
%A Imtiaz, Mohammed A
%A Krüger, Dennis Manfred
%A Centeno, Tonatiuh Pena
%A Aziz, N Ahmad
%A Fischer, Andre
%A Breteler, Monique M B
%T Peripheral whole blood microRNA expression in relation to vascular function: a population-based study.
%J Journal of translational medicine
%V 22
%N 1
%@ 1479-5876
%C London
%I BioMed Central
%M DZNE-2024-00898
%P 670
%D 2024
%X As key regulators of gene expression, microRNAs affect many cardiovascular mechanisms and have been associated with several cardiovascular diseases. In this study, we aimed to investigate the relation of whole blood microRNAs with several quantitative measurements of vascular function, and explore their biological role through an integrative microRNA-gene expression analysis.Peripheral whole blood microRNA expression was assessed through RNA-Seq in 2606 participants (45.8
%K Humans
%K Male
%K Middle Aged
%K Female
%K MicroRNAs: blood
%K MicroRNAs: genetics
%K Aged
%K Adult
%K Aged, 80 and over
%K Gene Regulatory Networks
%K Gene Expression Regulation
%K Blood Vessels: physiology
%K Cohort Studies
%K Gene Ontology
%K Gene Expression Profiling
%K Arterial compliance (Other)
%K Biomarkers (Other)
%K Blood microRNA (Other)
%K Cardiac output (Other)
%K Epigenomics (Other)
%K Population-based (Other)
%K Vascular function (Other)
%K WGCNA (Other)
%K White matter hyperintensity (Other)
%K microRNA-gene regulatory networks (Other)
%K MicroRNAs (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%2 pmc:PMC11264787
%$ pmid:39030538
%R 10.1186/s12967-024-05407-0
%U https://pub.dzne.de/record/270807