TY  - JOUR
AU  - Talevi, Valentina
AU  - Melas, Konstantinos
AU  - Pehlivan, Gökhan
AU  - Imtiaz, Mohammed A
AU  - Krüger, Dennis Manfred
AU  - Centeno, Tonatiuh Pena
AU  - Aziz, N Ahmad
AU  - Fischer, Andre
AU  - Breteler, Monique M B
TI  - Peripheral whole blood microRNA expression in relation to vascular function: a population-based study.
JO  - Journal of translational medicine
VL  - 22
IS  - 1
SN  - 1479-5876
CY  - London
PB  - BioMed Central
M1  - DZNE-2024-00898
SP  - 670
PY  - 2024
AB  - As key regulators of gene expression, microRNAs affect many cardiovascular mechanisms and have been associated with several cardiovascular diseases. In this study, we aimed to investigate the relation of whole blood microRNAs with several quantitative measurements of vascular function, and explore their biological role through an integrative microRNA-gene expression analysis.Peripheral whole blood microRNA expression was assessed through RNA-Seq in 2606 participants (45.8
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Female
KW  - MicroRNAs: blood
KW  - MicroRNAs: genetics
KW  - Aged
KW  - Adult
KW  - Aged, 80 and over
KW  - Gene Regulatory Networks
KW  - Gene Expression Regulation
KW  - Blood Vessels: physiology
KW  - Cohort Studies
KW  - Gene Ontology
KW  - Gene Expression Profiling
KW  - Arterial compliance (Other)
KW  - Biomarkers (Other)
KW  - Blood microRNA (Other)
KW  - Cardiac output (Other)
KW  - Epigenomics (Other)
KW  - Population-based (Other)
KW  - Vascular function (Other)
KW  - WGCNA (Other)
KW  - White matter hyperintensity (Other)
KW  - microRNA-gene regulatory networks (Other)
KW  - MicroRNAs (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC11264787
C6  - pmid:39030538
DO  - DOI:10.1186/s12967-024-05407-0
UR  - https://pub.dzne.de/record/270807
ER  -