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000270868 1001_ $$00000-0001-8831-858X$$aDelling, Jan Philipp$$b0
000270868 245__ $$aCombined expansion and STED microscopy reveals altered fingerprints of postsynaptic nanostructure across brain regions in ASD-related SHANK3-deficiency.
000270868 260__ $$aLondon$$bMacmillan$$c2024
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000270868 520__ $$aSynaptic dysfunction is a key feature of SHANK-associated disorders such as autism spectrum disorder, schizophrenia, and Phelan-McDermid syndrome. Since detailed knowledge of their effect on synaptic nanostructure remains limited, we aimed to investigate such alterations in ex11|SH3 SHANK3-KO mice combining expansion and STED microscopy. This enabled high-resolution imaging of mosaic-like arrangements formed by synaptic proteins in both human and murine brain tissue. We found distinct shape-profiles as fingerprints of the murine postsynaptic scaffold across brain regions and genotypes, as well as alterations in the spatial and molecular organization of subsynaptic domains under SHANK3-deficient conditions. These results provide insights into synaptic nanostructure in situ and advance our understanding of molecular mechanisms underlying synaptic dysfunction in neuropsychiatric disorders.
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000270868 650_2 $$2MeSH$$aAnimals
000270868 650_2 $$2MeSH$$aFemale
000270868 650_2 $$2MeSH$$aHumans
000270868 650_2 $$2MeSH$$aMice
000270868 650_2 $$2MeSH$$aAutism Spectrum Disorder: genetics
000270868 650_2 $$2MeSH$$aAutism Spectrum Disorder: metabolism
000270868 650_2 $$2MeSH$$aBrain: metabolism
000270868 650_2 $$2MeSH$$aBrain: pathology
000270868 650_2 $$2MeSH$$aChromosome Deletion
000270868 650_2 $$2MeSH$$aChromosome Disorders
000270868 650_2 $$2MeSH$$aChromosomes, Human, Pair 22
000270868 650_2 $$2MeSH$$aMice, Inbred C57BL
000270868 650_2 $$2MeSH$$aMice, Knockout
000270868 650_2 $$2MeSH$$aMicrofilament Proteins: metabolism
000270868 650_2 $$2MeSH$$aMicrofilament Proteins: genetics
000270868 650_2 $$2MeSH$$aMicroscopy: methods
000270868 650_2 $$2MeSH$$aNerve Tissue Proteins: metabolism
000270868 650_2 $$2MeSH$$aNerve Tissue Proteins: genetics
000270868 650_2 $$2MeSH$$aSynapses: metabolism
000270868 650_2 $$2MeSH$$aYoung Adult
000270868 7001_ $$aBauer, Helen Friedericke$$b1
000270868 7001_ $$aGerlach-Arbeiter, Susanne$$b2
000270868 7001_ $$aSchön, Michael$$b3
000270868 7001_ $$aJacob, Christian$$b4
000270868 7001_ $$aWagner, Jan$$b5
000270868 7001_ $$aPedro, Maria Teresa$$b6
000270868 7001_ $$aKnöll, Bernd$$b7
000270868 7001_ $$0P:(DE-2719)2812855$$aBoeckers, Tobias M$$b8$$eLast author
000270868 773__ $$0PERI:(DE-600)1502531-7$$a10.1038/s41380-024-02559-9$$n10$$p2997 - 3009$$tMolecular psychiatry$$v29$$x1359-4184$$y2024
000270868 7870_ $$0DZNE-2024-00906$$aDelling, Jan Philipp et.al.$$dEdmond, 2024$$iRelatedTo$$r$$tData, code, and images underlying figures in the manuscript 'Combined expansion and STED microscopy reveals altered fingerprints of postsynaptic nanostructure across brain regions in ASD-related SHANK3-deficiency'
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