%0 Journal Article
%A Preis, Lukas
%A Villringer, Kersten
%A Brosseron, Frederic
%A Düzel, Emrah
%A Jessen, Frank
%A Petzold, Gabor C
%A Ramirez, Alfredo
%A Spottke, Annika
%A Fiebach, Jochen B
%A Peters, Oliver
%T Assessing blood-brain barrier dysfunction and its association with Alzheimer's pathology, cognitive impairment and neuroinflammation.
%J Alzheimer's research & therapy
%V 16
%N 1
%@ 1758-9193
%C London
%I BioMed Central
%M DZNE-2024-00934
%P 172
%D 2024
%X Blood-brain barrier (BBB) alterations may contribute to AD pathology through various mechanisms, including impaired amyloid-β (Aβ) clearance and neuroinflammation. Soluble platelet-derived growth factor receptor beta (sPDGFRβ) has emerged as a potential biomarker for BBB integrity. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) offers a direct assessment of BBB permeability. However, the relationship between BBB dysfunction, cognitive impairment, and AD pathology remains unclear, with inconsistent findings in the literature.We conducted a cross-sectional study using data from the DELCODE and DESCRIBE cohorts to investigate BBB dysfunction in participants with normal cognition (NC), mild cognitive impairment (MCI), and AD dementia. BBB function was assessed using DCE-MRI and sPDGFRβ levels in cerebrospinal fluid and AD biomarkers Aβ and tau were measured. In a subset of patients, the CSF/plasma-ratio of albumin (QAlb) as a standard marker of BBB integrity and markers of neuroinflammation were analyzed.91 participants (NC: 44, MCI: 21, AD: 26) were included in the analysis. The average age was 74.4 years, 42
%K Humans
%K Blood-Brain Barrier: pathology
%K Female
%K Cognitive Dysfunction: diagnostic imaging
%K Cognitive Dysfunction: pathology
%K Male
%K Aged
%K Alzheimer Disease: diagnostic imaging
%K Alzheimer Disease: pathology
%K Cross-Sectional Studies
%K Magnetic Resonance Imaging
%K Neuroinflammatory Diseases: diagnostic imaging
%K Neuroinflammatory Diseases: pathology
%K Amyloid beta-Peptides: cerebrospinal fluid
%K Amyloid beta-Peptides: metabolism
%K Biomarkers: cerebrospinal fluid
%K Biomarkers: blood
%K Middle Aged
%K Aged, 80 and over
%K Receptor, Platelet-Derived Growth Factor beta: metabolism
%K tau Proteins: cerebrospinal fluid
%K tau Proteins: metabolism
%K Alzheimer’s disease (Other)
%K Alzheimer’s disease (Other)
%K Blood-brain barrier (Other)
%K DCE-MRI (Other)
%K Mild cognitive impairment (Other)
%K Pericyte (Other)
%K sPDGFRβ (Other)
%K Amyloid beta-Peptides (NLM Chemicals)
%K Biomarkers (NLM Chemicals)
%K Receptor, Platelet-Derived Growth Factor beta (NLM Chemicals)
%K tau Proteins (NLM Chemicals)
%K sPDGFRβ (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39085945
%2 pmc:PMC11290219
%R 10.1186/s13195-024-01529-1
%U https://pub.dzne.de/record/271062