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000271063 1001_ $$0P:(DE-2719)9000722$$aRiemann, Steffen$$b0$$udzne
000271063 245__ $$aThe role of frontal cortex in novel-word learning and consolidation: Evidence from focal transcranial direct current stimulation.
000271063 260__ $$aNew York, NY$$bElsevier$$c2024
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000271063 520__ $$aPrevious studies have demonstrated that conventional transcranial direct current stimulation (tDCS) can enhance novel-word learning. However, because of the widespread current that is induced by these setups and lack of appropriate control conditions, little is known about the underlying neural mechanisms. In the present double-blinded and sham-tDCS controlled study, we investigated for the first time if regionally precise focal tDCS targeting two key nodes of the novel-word learning network at different time points would result in regionally and temporally distinct effects. 156 participants completed a contextual novel-word-learning paradigm and learning success was probed immediately after the acquisition period and 30-min later. Participants were randomly assigned to six stimulation conditions: Active tDCS (1.5 mA) was administered to left inferior frontal (IFG) or middle temporal gyrus (MTG), either during acquisition or delayed recall. Control groups received sham-tDCS either during acquisition or delayed recall (50% IFG/MTG). Data were analyzed with a generalized linear mixed model with a binomial link function in a Bayesian framework. Our results showed that frontal tDCS selectively increased accuracy gains from immediate to delayed recall, irrespective of timing of the stimulation. There was no evidence for beneficial effects of middle temporal gyrus tDCS. Our findings confirm that IFG tDCS can enhance novel-word learning in a regionally, but not timing specific way. Tentatively, this may be explained by enhancement of semantic selection processes resulting in more effective consolidation and/or retrieval. Future studies using longer time intervals between assessments are required to clarify the potential contribution of neurophysiological after-effects of IFG tDCS administered during acquisition to enhanced consolidation.
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000271063 650_7 $$2Other$$aInferior frontal gyrus
000271063 650_7 $$2Other$$aMiddle temporal gyrus
000271063 650_7 $$2Other$$aNovel word learning
000271063 650_7 $$2Other$$aRegional specificity
000271063 650_7 $$2Other$$aTemporal specificity
000271063 650_7 $$2Other$$afocal tDCS
000271063 650_2 $$2MeSH$$aHumans
000271063 650_2 $$2MeSH$$aTranscranial Direct Current Stimulation: methods
000271063 650_2 $$2MeSH$$aMale
000271063 650_2 $$2MeSH$$aFemale
000271063 650_2 $$2MeSH$$aAdult
000271063 650_2 $$2MeSH$$aFrontal Lobe: physiology
000271063 650_2 $$2MeSH$$aYoung Adult
000271063 650_2 $$2MeSH$$aLearning: physiology
000271063 650_2 $$2MeSH$$aDouble-Blind Method
000271063 650_2 $$2MeSH$$aMental Recall: physiology
000271063 650_2 $$2MeSH$$aTemporal Lobe: physiology
000271063 650_2 $$2MeSH$$aMemory Consolidation: physiology
000271063 7001_ $$avan Lück, Jil$$b1
000271063 7001_ $$aRodríguez-Fornells, Antoni$$b2
000271063 7001_ $$0P:(DE-2719)2812683$$aFlöel, Agnes$$b3$$udzne
000271063 7001_ $$aMeinzer, Marcus$$b4
000271063 773__ $$0PERI:(DE-600)2080335-7$$a10.1016/j.cortex.2024.05.004$$gVol. 177, p. 15 - 27$$p15 - 27$$tCortex$$v177$$x0010-9452$$y2024
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