Home > Publications Database > The role of frontal cortex in novel-word learning and consolidation: Evidence from focal transcranial direct current stimulation. > print

001     271063
005     20240808121355.0
024 7 _ |a 10.1016/j.cortex.2024.05.004
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024 7 _ |a 0010-9452
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024 7 _ |a 1973-8102
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037 _ _ |a DZNE-2024-00935
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Riemann, Steffen
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245 _ _ |a The role of frontal cortex in novel-word learning and consolidation: Evidence from focal transcranial direct current stimulation.
260 _ _ |a New York, NY
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336 7 _ |a article
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520 _ _ |a Previous studies have demonstrated that conventional transcranial direct current stimulation (tDCS) can enhance novel-word learning. However, because of the widespread current that is induced by these setups and lack of appropriate control conditions, little is known about the underlying neural mechanisms. In the present double-blinded and sham-tDCS controlled study, we investigated for the first time if regionally precise focal tDCS targeting two key nodes of the novel-word learning network at different time points would result in regionally and temporally distinct effects. 156 participants completed a contextual novel-word-learning paradigm and learning success was probed immediately after the acquisition period and 30-min later. Participants were randomly assigned to six stimulation conditions: Active tDCS (1.5 mA) was administered to left inferior frontal (IFG) or middle temporal gyrus (MTG), either during acquisition or delayed recall. Control groups received sham-tDCS either during acquisition or delayed recall (50% IFG/MTG). Data were analyzed with a generalized linear mixed model with a binomial link function in a Bayesian framework. Our results showed that frontal tDCS selectively increased accuracy gains from immediate to delayed recall, irrespective of timing of the stimulation. There was no evidence for beneficial effects of middle temporal gyrus tDCS. Our findings confirm that IFG tDCS can enhance novel-word learning in a regionally, but not timing specific way. Tentatively, this may be explained by enhancement of semantic selection processes resulting in more effective consolidation and/or retrieval. Future studies using longer time intervals between assessments are required to clarify the potential contribution of neurophysiological after-effects of IFG tDCS administered during acquisition to enhanced consolidation.
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650 _ 7 |a Inferior frontal gyrus
|2 Other
650 _ 7 |a Middle temporal gyrus
|2 Other
650 _ 7 |a Novel word learning
|2 Other
650 _ 7 |a Regional specificity
|2 Other
650 _ 7 |a Temporal specificity
|2 Other
650 _ 7 |a focal tDCS
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Transcranial Direct Current Stimulation: methods
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Frontal Lobe: physiology
|2 MeSH
650 _ 2 |a Young Adult
|2 MeSH
650 _ 2 |a Learning: physiology
|2 MeSH
650 _ 2 |a Double-Blind Method
|2 MeSH
650 _ 2 |a Mental Recall: physiology
|2 MeSH
650 _ 2 |a Temporal Lobe: physiology
|2 MeSH
650 _ 2 |a Memory Consolidation: physiology
|2 MeSH
700 1 _ |a van Lück, Jil
|b 1
700 1 _ |a Rodríguez-Fornells, Antoni
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700 1 _ |a Flöel, Agnes
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700 1 _ |a Meinzer, Marcus
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773 _ _ |a 10.1016/j.cortex.2024.05.004
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