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@ARTICLE{Statz:271077,
      author       = {Statz, Meike and Weber, Hanna and Weis, Frederike and
                      Kober, Maria and Bathel, Henning and Plocksties, Franz and
                      van Rienen, Ursula and Timmermann, Dirk and Storch,
                      Alexander and Fauser, Mareike},
      title        = {{S}ubthalamic nucleus deep brain stimulation induces
                      functional deficits in norepinephrinergic neurotransmission
                      in a {P}arkinson’s disease model},
      journal      = {Brain research},
      volume       = {1841},
      issn         = {0006-8993},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DZNE-2024-00949},
      pages        = {149128},
      year         = {2024},
      abstract     = {Deep brain stimulation of the subthalamic nucleus (STN-DBS)
                      is a successful treatment option in Parkinson's disease (PD)
                      for different motor and non-motor symptoms, but has been
                      linked to postoperative cognitive impairment.Since both
                      dopaminergic and norepinephrinergic neurotransmissions play
                      important roles in symptom development, we analysed STN-DBS
                      effects on dopamine and norepinephrine availability in
                      different brain regions and morphological alterations of
                      catecholaminergic neurons in the 6-hydroxydopamine PD rat
                      model.We applied one week of continuous unilateral STN-DBS
                      or sham stimulation, respectively, in groups of healthy and
                      6-hydroxydopamine-lesioned rats to quantify dopamine and
                      norepinephrine contents in the striatum, olfactory bulb and
                      dentate gyrus. In addition, we analysed dopaminergic cell
                      counts in the substantia nigra pars compacta and area
                      tegmentalis ventralis and norepinephrinergic neurons in the
                      locus coeruleus after one and six weeks of STN-DBS.In
                      6-hydroxydopamine-lesioned animals, one week of STN-DBS did
                      not alter dopamine levels, while striatal norepinephrine
                      levels were decreased. However, neither one nor six weeks of
                      STN-DBS altered dopaminergic neuron numbers in the midbrain
                      or norepinephrinergic neuron counts in the locus coeruleus.
                      Dopaminergic fibre density in the dorsal and ventral
                      striatum also remained unchanged after six weeks of STN-DBS.
                      In healthy animals, one week of STN-DBS resulted in
                      increased dopamine levels in the olfactory bulb and
                      decreased contents in the dentate gyrus, but had no effects
                      on norepinephrine availability.STN-DBS modulates striatal
                      norepinephrinergic neurotransmission in a PD rat model.
                      Additional behavioural studies are required to investigate
                      the functional impact of this finding.},
      keywords     = {Animals / Subthalamic Nucleus: metabolism / Deep Brain
                      Stimulation: methods / Male / Oxidopamine: toxicity /
                      Synaptic Transmission: physiology / Dopamine: metabolism /
                      Disease Models, Animal / Norepinephrine: metabolism / Rats /
                      Parkinson Disease: metabolism / Parkinson Disease: therapy /
                      Dopaminergic Neurons: metabolism / Olfactory Bulb:
                      metabolism / Rats, Sprague-Dawley / Corpus Striatum:
                      metabolism / Dentate Gyrus: metabolism / Parkinsonian
                      Disorders: metabolism / Parkinsonian Disorders: therapy /
                      Parkinsonian Disorders: physiopathology},
      cin          = {AG Storch},
      ddc          = {610},
      cid          = {I:(DE-2719)5000014},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39053685},
      doi          = {10.1016/j.brainres.2024.149128},
      url          = {https://pub.dzne.de/record/271077},
}