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000271084 1001_ $$aWormuth, Carola$$b0
000271084 245__ $$aA Novel Rat Infant Model of Medial Temporal Lobe Epilepsy Reveals New Insight into the Molecular Biology and Epileptogenesis in the Developing Brain.
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000271084 520__ $$aAlthough several adult rat models of medial temporal lobe epilepsy (mTLE) have been described in detail, our knowledge of mTLE epileptogenesis in infant rats is limited. Here, we present a novel infant rat model of mTLE (InfRPil-mTLE) based on a repetitive, triphasic injection regimen consisting of low-dose pilocarpine administrations (180 mg/kg. i.p.) on days 9, 11, and 15 post partum (pp). The model had a survival rate of >80% and exhibited characteristic spontaneous recurrent electrographic seizures (SRES) in both the hippocampus and cortex that persisted into adulthood. Using implantable video-EEG radiotelemetry, we quantified a complex set of seizure parameters that demonstrated the induction of chronic electroencephalographic seizure activity in our InfRPil-mTLE model, which predominated during the dark cycle. We further analyzed selected candidate genes potentially relevant to epileptogenesis using a RT-qPCR approach. Several candidates, such as the low-voltage-activated Ca2+ channel Cav3.2 and the auxiliary subunits β 1 and β 2, which were previously reported to be upregulated in the hippocampus of the adult pilocarpine mTLE model, were found to be downregulated (together with Cav2.1, Cav2.3, M1, and M3) in the hippocampus and cortex of our InfRPil-mTLE model. From a translational point of view, our model could serve as a blueprint for childhood epileptic disorders and further contribute to antiepileptic drug research and development in the future.
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000271084 650_7 $$001MI4Q9DI3$$2NLM Chemicals$$aPilocarpine
000271084 650_2 $$2MeSH$$aAnimals
000271084 650_2 $$2MeSH$$aEpilepsy, Temporal Lobe: physiopathology
000271084 650_2 $$2MeSH$$aEpilepsy, Temporal Lobe: genetics
000271084 650_2 $$2MeSH$$aEpilepsy, Temporal Lobe: metabolism
000271084 650_2 $$2MeSH$$aEpilepsy, Temporal Lobe: chemically induced
000271084 650_2 $$2MeSH$$aDisease Models, Animal
000271084 650_2 $$2MeSH$$aRats
000271084 650_2 $$2MeSH$$aPilocarpine
000271084 650_2 $$2MeSH$$aElectroencephalography
000271084 650_2 $$2MeSH$$aHippocampus: metabolism
000271084 650_2 $$2MeSH$$aAnimals, Newborn
000271084 650_2 $$2MeSH$$aBrain: metabolism
000271084 650_2 $$2MeSH$$aRats, Sprague-Dawley
000271084 650_2 $$2MeSH$$aMale
000271084 650_2 $$2MeSH$$aFemale
000271084 7001_ $$aPapazoglou, Anna$$b1
000271084 7001_ $$aHenseler, Christina$$b2
000271084 7001_ $$0P:(DE-2719)2289209$$aEhninger, Dan$$b3$$udzne
000271084 7001_ $$aBroich, Karl$$b4
000271084 7001_ $$0P:(DE-2719)2810511$$aHaenisch, Britta$$b5$$udzne
000271084 7001_ $$aHescheler, Jürgen$$b6
000271084 7001_ $$aKöhling, Rüdiger$$b7
000271084 7001_ $$00000-0002-6058-4752$$aWeiergräber, Marco$$b8
000271084 773__ $$0PERI:(DE-600)2236872-3$$a10.1155/2024/9946769$$gVol. 2024, no. 1, p. 9946769$$n1$$p9946769$$tNeural plasticity$$v2024$$x2090-5904$$y2024
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