TY  - JOUR
AU  - Wormuth, Carola
AU  - Papazoglou, Anna
AU  - Henseler, Christina
AU  - Ehninger, Dan
AU  - Broich, Karl
AU  - Haenisch, Britta
AU  - Hescheler, Jürgen
AU  - Köhling, Rüdiger
AU  - Weiergräber, Marco
TI  - A Novel Rat Infant Model of Medial Temporal Lobe Epilepsy Reveals New Insight into the Molecular Biology and Epileptogenesis in the Developing Brain.
JO  - Neural plasticity
VL  - 2024
IS  - 1
SN  - 2090-5904
CY  - New York, NY
PB  - Hindawi
M1  - DZNE-2024-00956
SP  - 9946769
PY  - 2024
AB  - Although several adult rat models of medial temporal lobe epilepsy (mTLE) have been described in detail, our knowledge of mTLE epileptogenesis in infant rats is limited. Here, we present a novel infant rat model of mTLE (InfRPil-mTLE) based on a repetitive, triphasic injection regimen consisting of low-dose pilocarpine administrations (180 mg/kg. i.p.) on days 9, 11, and 15 post partum (pp). The model had a survival rate of >80
KW  - Animals
KW  - Epilepsy, Temporal Lobe: physiopathology
KW  - Epilepsy, Temporal Lobe: genetics
KW  - Epilepsy, Temporal Lobe: metabolism
KW  - Epilepsy, Temporal Lobe: chemically induced
KW  - Disease Models, Animal
KW  - Rats
KW  - Pilocarpine
KW  - Electroencephalography
KW  - Hippocampus: metabolism
KW  - Animals, Newborn
KW  - Brain: metabolism
KW  - Rats, Sprague-Dawley
KW  - Male
KW  - Female
KW  - Pilocarpine (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:39104708
C2  - pmc:PMC11300100
DO  - DOI:10.1155/2024/9946769
UR  - https://pub.dzne.de/record/271084
ER  -